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1994-08-27
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Document 0799
DOCN M9480799
TI Adverse reactions to dapsone in persons infected with human
immunodeficiency virus.
DT 9410
AU Pertel P; Hirschtick R; Division of Infectious Diseases, Northwestern
University, Medical; School, Chicago, Illinois 60611.
SO Clin Infect Dis. 1994 Apr;18(4):630-2. Unique Identifier : AIDSLINE
MED/94312566
AB Dapsone is used in prophylaxis for and treatment of Pneumocystis carinii
pneumonia. We present a case of Stevens-Johnson syndrome that was likely
induced by administration of dapsone. A review of charts at the HIV
Treatment Center of Northwestern University (Chicago) revealed that
40.3% of patients treated with trimethoprim-sulfamethoxazole could not
tolerate the medication, while 25.2% of those treated with dapsone were
intolerant of the drug. We also found a higher rate of adverse reactions
to dapsone among patients with prior intolerance to
trimethoprim-sulfamethoxazole than among patients without such a
history; however, the difference was not significant.
DE Acquired Immunodeficiency Syndrome/*DRUG THERAPY Adult Case Report
Dapsone/*ADVERSE EFFECTS Drug Tolerance Human Male Pneumonia,
Pneumocystis carinii/PREVENTION & CONTROL Stevens-Johnson
Syndrome/*CHEMICALLY INDUCED Support, Non-U.S. Gov't
Trimethoprim-Sulfamethoxazole Combination/ADVERSE EFFECTS JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).