Document 0799
 DOCN  M9480799
 TI    Adverse reactions to dapsone in persons infected with human
       immunodeficiency virus.
 DT    9410
 AU    Pertel P; Hirschtick R; Division of Infectious Diseases, Northwestern
       University, Medical; School, Chicago, Illinois 60611.
 SO    Clin Infect Dis. 1994 Apr;18(4):630-2. Unique Identifier : AIDSLINE
       MED/94312566
 AB    Dapsone is used in prophylaxis for and treatment of Pneumocystis carinii
       pneumonia. We present a case of Stevens-Johnson syndrome that was likely
       induced by administration of dapsone. A review of charts at the HIV
       Treatment Center of Northwestern University (Chicago) revealed that
       40.3% of patients treated with trimethoprim-sulfamethoxazole could not
       tolerate the medication, while 25.2% of those treated with dapsone were
       intolerant of the drug. We also found a higher rate of adverse reactions
       to dapsone among patients with prior intolerance to
       trimethoprim-sulfamethoxazole than among patients without such a
       history; however, the difference was not significant.
 DE    Acquired Immunodeficiency Syndrome/*DRUG THERAPY  Adult  Case Report
       Dapsone/*ADVERSE EFFECTS  Drug Tolerance  Human  Male  Pneumonia,
       Pneumocystis carinii/PREVENTION & CONTROL  Stevens-Johnson
       Syndrome/*CHEMICALLY INDUCED  Support, Non-U.S. Gov't
       Trimethoprim-Sulfamethoxazole Combination/ADVERSE EFFECTS  JOURNAL
       ARTICLE

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