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1994-08-27
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Document 0800
DOCN M9480800
TI Cyclospora: a newly identified intestinal pathogen of humans.
DT 9410
AU Wurtz R; Division of Infectious Disease, Cook County Hospital, Chicago,;
Illinois 60612.
SO Clin Infect Dis. 1994 Apr;18(4):620-3. Unique Identifier : AIDSLINE
MED/94312563
AB A number of reports over the last several years have linked a previously
unidentified acid-fast organism with prolonged diarrhea in humans.
Initially thought to be a cyanobacterium, the organism has been
identified as a coccidian protozoan of the genus Cyclospora, and the
name Cyclospora cayetanensis has been proposed. Organisms that resemble
Cyclospora protozoa have been discovered in human stool samples around
the world and have been isolated from children, immunocompetent adults,
and human immunodeficiency virus (HIV)-seropositive individuals. The
apparently waterborne organisms cause disease predominantly in summer
months. In wet mounts of fresh stool specimens, the organisms are
wrinkled spheres of 8-9 microns in diameter, with well-defined
nonrefractile external walls and internal granular material, and
resemble large oocysts of Cryptosporidium species. Organisms fluoresce
under ultraviolet illumination. Formalin-preserved oocysts are variably
acid-fast, and the results of staining with the modified carbolfuchsin
technique (which is used to stain Cryptosporidium species) range from no
staining to deep-red staining. The clinical syndrome is characterized by
watery diarrhea (approximately 6 stools/day), nausea, anorexia,
abdominal cramping, fatigue, and weight loss. Diarrhea appears to be
self-limiting in the immunocompetent host but may be prolonged in
patients with advanced HIV infection. Symptoms have abated in a handful
of people treated with trimethoprim-sulfamethoxazole. Many questions
remain to be answered about this newly identified pathogen.
DE Animal Coccidia/CLASSIFICATION/ISOLATION & PURIF/*PATHOGENICITY
Coccidiosis/EPIDEMIOLOGY/*PARASITOLOGY/TRANSMISSION Developing
Countries Diarrhea/EPIDEMIOLOGY/*PARASITOLOGY Human Water Supply
JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).