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1994-08-27
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Document 0798
DOCN M9480798
TI Progressive immunodeficiency due to infection with human
immunodeficiency virus does not lead to waning immunity to measles in a
cohort of homosexual men.
DT 9410
AU Zolopa AR; Kemper CA; Shiboski S; Hamilton JR; Moss AR; Deresinski SC;
Department of Epidemiology and Biostatistics, University of; California,
San Francisco 94110.
SO Clin Infect Dis. 1994 Apr;18(4):636-8. Unique Identifier : AIDSLINE
MED/94312568
AB The relationship between progressive immunodeficiency related to
infection with human immunodeficiency virus (HIV) and waning immunity to
measles was investigated in this retrospective cohort study. Titers of
serum antibodies to measles virus were measured by enzyme immunoassay of
stored sera from a cohort of homosexual men who were studied at San
Francisco General Hospital. Subjects underwent a baseline and follow-up
measure of measles antibodies. High levels of antibodies to measles
virus were maintained in the HIV-positive and negative groups. One (2%)
of the 50 HIV-negative controls was seronegative for the measles virus,
and no controls evidenced seroreversal (decline in antibody to a level
at which protection is not provided) during the study. Two (1.4%) of the
145 HIV-positive subjects were measles-seronegative, and two others
evidenced seroreversal. Analysis with Spearman's rank correlation
revealed no relationship between changes in the CD4 cell count and
measles antibody level. Thus we conclude that waning measles immunity is
not greatly accelerated in HIV-infected adults despite progressive
HIV-related immunodeficiency.
DE Adult Antibodies, Viral/BLOOD Cohort Studies Homosexuality Human
HIV Infections/EPIDEMIOLOGY/*IMMUNOLOGY Immune Tolerance Male
Measles/EPIDEMIOLOGY/*IMMUNOLOGY Measles Virus/IMMUNOLOGY
Retrospective Studies San Francisco/EPIDEMIOLOGY Support, Non-U.S.
Gov't Time Factors JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).