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- 020.18: Molecular Biology: ICGEBnet
- by Sandor Pongor, Gyorgy Simon and Arturo Falaschi
- <pongor@icgeb.trieste.it>
- <simon@icgeb.trieste.it>
- <falaschi@icgeb.trieste.it>
-
-
- The International Centre for Genetic Engineering and
- Biotechnology (ICGEB) is an institute operated by the United
- Nations Industrial Development Organization to help developing
- countries strengthen their research abilities in molecular
- biology and to provide information on various biotech-related
- issues such as biosafety and patenting. ICGEB has two research
- components, situated in Trieste, Italy and New Delhi, India.
-
- One of the fundamental tools in molecular biology is access to
- gene sequence databases. Mega-projects, such as the sequencing
- of the human genome in the US, are pouring data into the
- databanks. Every time a new gene or protein sequence is
- determined experimentally, researchers must search these
- databanks for similar sequences.
-
- This task is far beyond the reach of small computers and is best
- done by using centralized computer resources such as maintained
- by EMBL (the European Molecular Biology Laboratory) in Europe or
- GenBank in the US. In addition to access to the databases, these
- systems provide services such as electronic mail, bulletin
- boards, and access to file archives.
-
- ICGEB provides a similar resource for developing countries.
- ICGEBnet provides on-line access to the major sequence data
- banks, including the EMBL nucleic acid sequence databank which is
- updated daily. ICGEBnet is a node of EMBnet, the informatics
- network of the European Molecular Biology Organization.
-
- In addition to the EMBL data bank, ICGEB supports a wide variety
- of other data resources, such as the HIV sequence databases
- HIV-NA and HIV-AA, the Japanese Protein Research Foundation's
- protein sequence database SEQDB, and the SBASE protein domain
- library (developed at ICGEB).
-
- On-line software includes packages for representing and
- manipulating nucleic acid and protein sequence data, as well as
- FASTA and TFASTA for sequence similarity searching, and CLUSTAL
- for multiple sequence alignment. Other utilities include
- electronic mail, a bulletin board, and the gopher service.
-
- Access to ICGEBnet resources is available to all ICGEB member
- country scientists; however, preference will be given to those
- scientists whose research is directly related to the research
- goals of ICGEB. The principal mechanism for remote access to the
- ICGEBnet is via the Italian ITAPAC X.25 PDN, permitting up to 16
- simultaneous incoming connections. In addition, ICGEBnet can also
- be accessed over the Internet via the International Centre for
- Theoretical Physics. At the end of 1991, ICGEBnet had 300
- registered users. ICGEBnet also serves as a training facility.
- The system is used extensively during the 15 or so ICGEB courses
- organized yearly, two of which are usually dedicated to computer
- applications. A computer lab at ICGEB can host up to 25
- students.
-
- ICGEBnet is maintained by ICGEB's Computer Services in
- collaboration with ICGEB's Protein Structure and Function Group.
- The joint research is focused on search methods for distant
- protein sequence homologies.
-
- (S.P. is Head of Protein Structure/Function Group, G.S. is
- Systems Manager and A.F. is General Director, ICGEB, Padriciano
- 99, Area di Ricerca, 34012 Trieste, Italy)
-