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- Newsgroups: comp.ai.genetic
- Path: sparky!uunet!spool.mu.edu!yale.edu!yale!gumby!destroyer!cs.ubc.ca!uw-beaver!pauld
- From: pauld@cs.washington.edu (Paul Barton-Davis)
- Subject: Re: So, genetic algorithms have nothing to do with genetics?
- Message-ID: <1993Jan21.094615.27344@beaver.cs.washington.edu>
- Sender: news@beaver.cs.washington.edu (USENET News System)
- Organization: Precipitating Pendulums Postal Party Poopers
- References: <1jlmb2INNjp4@gaia.ucs.orst.edu> <1993Jan21.092927.4669@CSD-NewsHost.Stanford.EDU>
- Date: Thu, 21 Jan 93 09:46:15 GMT
- Lines: 58
-
- In article <1993Jan21.092927.4669@CSD-NewsHost.Stanford.EDU> jek@Xenon.Stanford.EDU (James E. Kittock) writes:
- >In article <1jlmb2INNjp4@gaia.ucs.orst.edu> choup@ava.bcc.orst.edu (Ping Chou) writes:
- >
- >> Do you really believe the complete genome of HIV is just a 4-state
- >>bits encoded string?
- >
- >Well, in a sense, sure. Why? What do you know that we
- >don't? How about educate us rather than chastise us!
-
- Here's a start: its highly probable that variations in the physical
- structure of the DNA are intimately involved in regulating expression,
- both in the sense of levels (via histone binding) and process control
- (start, stop, splice points). This physical structure is
- simultaneously redundant (similar sequences can give rise to the same
- physical structure, within the limits of protein binding resolution
- anyway) but is also cross-correlated (you need <pattern-1> here, and
- <pattern2> there in order to get the effect).
-
- Although these effects are not completely lost by using a 4 state
- representation, they are considerably less obvious.
-
- >> Then please, give youself a chance, take a look at any modern
- >>genetics text book, and be a cross-discipline expert.
- >
- >It is pretty arrogant to assume that people who work
- >with genetic algorithms have no knowledge of genetics!
- >Furthermore, different people have different interests,
- >and you can't be sure what each person ought to study.
- >For example, there is relatively little need for
- >someone interested in modelling the evolution of
- >populations to have a thorough understanding of, say,
- >molecular biology even though it relates to genetics.
-
- Perhaps you could explain why you believe this to be so. I can think
- of several arguments against this.
-
- >For those non-biologists interested in getting some
- >background on cell physiology and/or genetics, I highly
- >recommend "The Living Cell", by Christian de Duve from
- >the Scientific American library series. It is getting
- >a bit "old" (1985?) but I assume the basic top-level
- >picture it presents is still mostly "correct". More
- >importantly it is scientific without being pedantic and
- >boring and yet it is not too "popular".
-
- If you can handle Alberts et al. "Molecular Biology of the Cell",
- you'll get more up to date info, nice pictures and lots of references.
- Also, see Ben Lewin's "Genes" for a mind-boggling view of just how
- complex biological genetics really is. You don't need to understand it
- all - just get a feel for the actual complexities.
-
- -- paul (ex-theoretical mol.biologist turned operating systems
- hacker and a-life private explorer)
- --
- hybrid rather than pure; compromising rather than clean; | Militant Agnostic
- distorted rather than straightforward; ambiguous rather than| I Don't Know
- articulated; both-and rather than either-or; the difficult | and You Don't
- unity of inclusion rather than the easy unity of exclusion. | Know Either
-