Document 0798
 DOCN  M9480798
 TI    Progressive immunodeficiency due to infection with human
       immunodeficiency virus does not lead to waning immunity to measles in a
       cohort of homosexual men.
 DT    9410
 AU    Zolopa AR; Kemper CA; Shiboski S; Hamilton JR; Moss AR; Deresinski SC;
       Department of Epidemiology and Biostatistics, University of; California,
       San Francisco 94110.
 SO    Clin Infect Dis. 1994 Apr;18(4):636-8. Unique Identifier : AIDSLINE
       MED/94312568
 AB    The relationship between progressive immunodeficiency related to
       infection with human immunodeficiency virus (HIV) and waning immunity to
       measles was investigated in this retrospective cohort study. Titers of
       serum antibodies to measles virus were measured by enzyme immunoassay of
       stored sera from a cohort of homosexual men who were studied at San
       Francisco General Hospital. Subjects underwent a baseline and follow-up
       measure of measles antibodies. High levels of antibodies to measles
       virus were maintained in the HIV-positive and negative groups. One (2%)
       of the 50 HIV-negative controls was seronegative for the measles virus,
       and no controls evidenced seroreversal (decline in antibody to a level
       at which protection is not provided) during the study. Two (1.4%) of the
       145 HIV-positive subjects were measles-seronegative, and two others
       evidenced seroreversal. Analysis with Spearman's rank correlation
       revealed no relationship between changes in the CD4 cell count and
       measles antibody level. Thus we conclude that waning measles immunity is
       not greatly accelerated in HIV-infected adults despite progressive
       HIV-related immunodeficiency.
 DE    Adult  Antibodies, Viral/BLOOD  Cohort Studies  Homosexuality  Human
       HIV Infections/EPIDEMIOLOGY/*IMMUNOLOGY  Immune Tolerance  Male
       Measles/EPIDEMIOLOGY/*IMMUNOLOGY  Measles Virus/IMMUNOLOGY
       Retrospective Studies  San Francisco/EPIDEMIOLOGY  Support, Non-U.S.
       Gov't  Time Factors  JOURNAL ARTICLE

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