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1994-08-27
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43 lines
Document 0668
DOCN M9480668
TI Effect of chronic feline immunodeficiency virus infection on
experimental feline calicivirus-induced disease.
DT 9410
AU Reubel GH; George JW; Higgins J; Pedersen NC; Department of Medicine,
School of Veterinary Medicine, University; of California, Davis 95616.
SO Vet Microbiol. 1994 Apr;39(3-4):335-51. Unique Identifier : AIDSLINE
MED/94317283
AB Acute feline calicivirus (FCV) infection caused a more severe disease in
chronically feline immunodeficiency virus (FIV) infected than in non-FIV
infected cats. FIV infected cats shed significantly higher amounts of
FCV through their saliva after FCV challenge than the non-FIV infected
cats. However, there was no difference in the duration of FCV shedding.
None of the cats exposed to FCV developed chronic FCV carriage. Both
groups of cats mounted similar titers of neutralizing antibodies to FCV.
Although FIV infected cats started out with significantly lower total
lymphocyte and neutrophil numbers than the non-FIV infected cats, the
transient lymphopenia and neutrophilia attributable to the FCV infection
was of similar intensity in both groups of animals. There was no
evidence that the underlying FIV-related disease or viremia was
influenced by acute FCV infection. Acute FCV infection did not
significantly alter the CD4+/CD8+ T lymphocyte ratio in FIV infected
compared to non-FIV infected cats. The ongoing humoral IgG response to
FIV was not affected by the FCV infection. There was no significant
change in the proportion of FIV infected peripheral blood mononuclear
cells during 8 subsequent weeks after FCV challenge as determined by
polymerase chain reaction.
DE Animal Antibodies, Viral/BLOOD Base Sequence Blotting, Southern
Caliciviridae Infections/COMPLICATIONS/*VETERINARY *Calicivirus,
Feline/IMMUNOLOGY/ISOLATION & PURIF Cats DNA Primers/CHEMISTRY DNA,
Viral/ANALYSIS Feline Acquired Immunodeficiency Syndrome/*COMPLICATIONS
Immunodeficiency Virus, Feline/GENETICS/IMMUNOLOGY/*PHYSIOLOGY
Leukocyte Count/VETERINARY Leukocytes, Mononuclear/MICROBIOLOGY
Molecular Sequence Data Oligonucleotide Probes/CHEMISTRY Polymerase
Chain Reaction Specific Pathogen-Free Organisms Support, U.S. Gov't,
P.H.S. Up-Regulation (Physiology) Virus Replication Virus Shedding
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).