Document 0668
 DOCN  M9480668
 TI    Effect of chronic feline immunodeficiency virus infection on
       experimental feline calicivirus-induced disease.
 DT    9410
 AU    Reubel GH; George JW; Higgins J; Pedersen NC; Department of Medicine,
       School of Veterinary Medicine, University; of California, Davis 95616.
 SO    Vet Microbiol. 1994 Apr;39(3-4):335-51. Unique Identifier : AIDSLINE
       MED/94317283
 AB    Acute feline calicivirus (FCV) infection caused a more severe disease in
       chronically feline immunodeficiency virus (FIV) infected than in non-FIV
       infected cats. FIV infected cats shed significantly higher amounts of
       FCV through their saliva after FCV challenge than the non-FIV infected
       cats. However, there was no difference in the duration of FCV shedding.
       None of the cats exposed to FCV developed chronic FCV carriage. Both
       groups of cats mounted similar titers of neutralizing antibodies to FCV.
       Although FIV infected cats started out with significantly lower total
       lymphocyte and neutrophil numbers than the non-FIV infected cats, the
       transient lymphopenia and neutrophilia attributable to the FCV infection
       was of similar intensity in both groups of animals. There was no
       evidence that the underlying FIV-related disease or viremia was
       influenced by acute FCV infection. Acute FCV infection did not
       significantly alter the CD4+/CD8+ T lymphocyte ratio in FIV infected
       compared to non-FIV infected cats. The ongoing humoral IgG response to
       FIV was not affected by the FCV infection. There was no significant
       change in the proportion of FIV infected peripheral blood mononuclear
       cells during 8 subsequent weeks after FCV challenge as determined by
       polymerase chain reaction.
 DE    Animal  Antibodies, Viral/BLOOD  Base Sequence  Blotting, Southern
       Caliciviridae Infections/COMPLICATIONS/*VETERINARY  *Calicivirus,
       Feline/IMMUNOLOGY/ISOLATION & PURIF  Cats  DNA Primers/CHEMISTRY  DNA,
       Viral/ANALYSIS  Feline Acquired Immunodeficiency Syndrome/*COMPLICATIONS
       Immunodeficiency Virus, Feline/GENETICS/IMMUNOLOGY/*PHYSIOLOGY
       Leukocyte Count/VETERINARY  Leukocytes, Mononuclear/MICROBIOLOGY
       Molecular Sequence Data  Oligonucleotide Probes/CHEMISTRY  Polymerase
       Chain Reaction  Specific Pathogen-Free Organisms  Support, U.S. Gov't,
       P.H.S.  Up-Regulation (Physiology)  Virus Replication  Virus Shedding
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).