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M94A0175.TXT
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1994-10-01
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Document 0175
DOCN M94A0175
TI T-cell-mediated immunopathology versus direct cytolysis by virus:
implications for HIV and AIDS.
DT 9412
AU Zinkernagel RM; Hengartner H; Institute of Experimental Immunology,
University of Zurich,; Switzerland.
SO Immunol Today. 1994 Jun;15(6):262-8. Unique Identifier : AIDSLINE
MED/94347174
AB It has been much debated as to whether CD4+ T-cell depletion and the
pathogenesis of AIDS is the result of direct cytolytic effects of human
immunodeficiency virus (HIV), T-cell apoptosis by nonspecific
activation, dysregulation of cytokine production, or autoimmunity. In
this context, Rolf Zinkernagel and Hans Hengartner discuss data from
model infections with non-cytopathic viruses. They suggest that HIV may
cause immunosuppression, not by direct cytolytic effects, but rather by
a conventional virus-specific cytotoxic T-cell-mediated immunopathology.
DE Acquired Immunodeficiency Syndrome/*IMMUNOLOGY Apoptosis/IMMUNOLOGY
Autoimmunity Human HIV/*IMMUNOLOGY HIV Infections/*IMMUNOLOGY
Lymphocyte Depletion Support, Non-U.S. Gov't T-Lymphocytes,
Cytotoxic/IMMUNOLOGY T-Lymphocytes, Suppressor-Effector/IMMUNOLOGY T4
Lymphocytes/*IMMUNOLOGY/PATHOLOGY JOURNAL ARTICLE REVIEW REVIEW,
TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).