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M94A0174.TXT
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1994-10-01
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Document 0174
DOCN M94A0174
TI Effect of serum from HIV-infected subjects on superoxide production by
polymorphonuclear neutrophils.
DT 9412
AU Pieri E; Orsilles MA; Laboratorio de Immunologia, Hospital Rawson,
Cordoba,; Argentina.
SO APMIS. 1994 Jun;102(6):427-31. Unique Identifier : AIDSLINE MED/94347331
AB Superoxide (O2.-) production by polymorphonuclear neutrophils (PMN) was
assessed in 17 subjects with asymptomatic infection (AI), 16 patients
with acquired immunodeficiency syndrome (AIDS), and 12 healthy normal
subjects. The effect of patients' serum on the oxidative activity of
normal and patients' PMN was also investigated. The O2.- production,
nonstimulated and stimulated with zymosan particles in the presence of
normal serum, was similar to that of normal controls in both groups of
patients. The serum from 11 out of the 17 AI subjects (65%) induced an
increase in the stimulated O2.- production in normal and patients' PMN,
while the serum from 8 out of the 16 AIDS patients (50%) induced a
diminution. These effects did not appear to be related to complement C3
and circulating immune complex levels, but suggest that PMN of
HIV-seropositive patients do not present an intrinsic dysfunction and
that the impact of serum factor(s) affects the normal oxidative activity
of these cells depending on the stage of infection.
DE Acquired Immunodeficiency Syndrome/*BLOOD Adult Blood
Proteins/*PHARMACOLOGY Comparative Study Complement 3/ANALYSIS Female
Human Male Middle Age Neutrophils/DRUG EFFECTS/*METABOLISM
Phagocytes/DRUG EFFECTS/METABOLISM Superoxides/*METABOLISM Support,
Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).