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M94A0075.TXT
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1994-10-01
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Document 0075
DOCN M94A0075
TI Temporal profile of hepatitis C virus antibody and genome in infants
born to mothers infected with hepatitis C virus but without human
immunodeficiency virus coinfection.
DT 9412
AU Ni YH; Lin HH; Chen PJ; Hsu HY; Chen DS; Chang MH; Department of
Pediatrics, College of Medicine, National Taiwan; University, Taipei,
R.O.C.
SO J Hepatol. 1994 May;20(5):641-5. Unique Identifier : AIDSLINE
MED/94351182
AB To investigate mother-to-infant transmission of hepatitis C virus,
serial follow-up of anti-HCV and hepatitis C virus RNA was undertaken in
11 infants born to hepatitis C virus-infected mothers who had been
screened from 11,688 pregnant women. None of the hepatitis C
virus-infected mothers was infected by human immunodeficiency virus.
Anti-HCV was checked by the second-generation enzyme immunoassay kit,
and hepatitis C virus RNA was examined by reverse transcriptase-nested
polymerase chain reaction. Hepatitis C virus RNA was found in more than
two serum samples in two of these 11 infants; those two infants were
regarded as hepatitis C virus-infected. One of the two had hepatitis C
virus RNA at the age of 1, 3, and 6 months, but not later. The course of
hepatitis C virus RNA and anti-HCV in this baby may reflect fluctuating
viral replication in chronic infectious disease or viral clearance in
acute infection. The other infant had hepatitis C virus RNA detectable
at the age of 3 months and at 15, 18 and 24 months. In the other nine
non-hepatitis C virus-infected infants, maternally acquired anti-HCV
gradually disappeared by the age of 6 months. The liver function profile
fell to the normal range in all the infants, including the two hepatitis
C virus-infected infants. This may indicate the subclinical nature of
hepatitis C virus infection in infancy. Seven fathers and four siblings
of these 11 infants were checked for anti-HCV and liver function tests;
none had evidence of hepatitis C virus infection.(ABSTRACT TRUNCATED AT
250 WORDS)
DE Base Sequence Female *Genome, Viral Hepatitis Antibodies/*ANALYSIS
Hepatitis C/COMPLICATIONS/*IMMUNOLOGY Hepatitis C
Viruses/*GENETICS/*IMMUNOLOGY Human HIV Infections/COMPLICATIONS
Infant, Newborn Maternal-Fetal Exchange Molecular Probes/GENETICS
Molecular Sequence Data Polymerase Chain Reaction Pregnancy Pregnancy
Complications, Infectious/*IMMUNOLOGY RNA, Viral/ANALYSIS Support,
Non-U.S. Gov't Time Factors Transcription, Genetic JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).