home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
The Pier Shareware 6
/
The_Pier_Shareware_Number_6_(The_Pier_Exchange)_(1995).iso
/
026
/
med9410a.zip
/
M94A0074.TXT
< prev
next >
Wrap
Text File
|
1994-10-01
|
1KB
|
26 lines
Document 0074
DOCN M94A0074
TI Use of suicide genes in gene therapy.
DT 9412
AU Tiberghien P; Histocompatibility and Immuno-Molecular Therapeutics
Laboratory,; Centre Regionale de Transfusion Sanguine, Besancon, France.
SO J Leukoc Biol. 1994 Aug;56(2):203-9. Unique Identifier : AIDSLINE
MED/94351257
AB Gene therapy encompasses a broad range of treatment modalities that may
eventually be applied to a variety of genetic as well as acquired
diseases. In addition to compensating for a defective gene--and
enhancing a cellular function--gene transfer can allow for a conditional
negative selection of target cells. Indeed, the transfer of a gene
encoding a susceptibility factor can make a cell specifically sensitive
to a drug. After genomic integration, such as potentially destructive
gene is endogenously expressed and has therefore been coined a suicide
gene. This review describes current experimental approaches and
prospects for using suicide genes for the treatment of human diseases.
DE Acquired Immunodeficiency Syndrome/THERAPY Animal Gene
Therapy/*METHODS Gene Transfer Human Neoplasms/THERAPY Neoplasms,
Experimental/THERAPY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).