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M9480861.TXT
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1994-09-05
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Document 0861
DOCN M9480861
TI A rapid sensitive, solution based fluorescent in situ hybridization
(FISH) assay for the detection of HIV mRNA in infected cell lines by
multi-colored flow cytometry.
DT 9410
AU Poindexter B; Cubbage M; Weber W; Ku J; Bresser J; Aprogenex, Inc.,
Houston, TX.
SO Abstr Gen Meet Am Soc Microbiol. 1994;94:483 (abstract no. T-3). Unique
Identifier : AIDSLINE ASM94/94313084
AB Rapid detection of low levels of HIV infected cells is necessary for the
screening of donated blood as well as in the clinical diagnosis of
infection. Aprogenex has developed an HIV diagnostic test, Virafy,
sensitive enough to detect infected cell lines diluted down to 1 in
10,000 with uninfected cell lines by flow cytometry. The test can be
performed in less than 1 hour and with the use of proprietary background
reducers and signal enhancers these low levels of detection can be
obtained. Other potential applications include determination of the
level of RNA infection in cells as well as the evaluation of therapeutic
regimens.
DE Flow Cytometry/*METHODS Human HIV/GENETICS/*ISOLATION & PURIF In Situ
Hybridization, Fluorescence/*METHODS Reagent Kits, Diagnostic RNA,
Messenger/*ANALYSIS Sensitivity and Specificity MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).