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  1.  
  2.  
  3.                              DISOPYRAMIDE
  4.  
  5.        BRAND NAMES
  6.            Norpace               Rythmodan
  7.            Norpace CR            Rythmodan-LA
  8.            
  9.        BASIC INFORMATION
  10.            Habit forming?  No
  11.            Prescription needed?  Yes
  12.            Available as generic?  Yes
  13.            Drug class:  Antiarrhythmic
  14.            
  15.        USES
  16.            Corrects heart rhythm disorders.
  17.            
  18.        DOSAGE AND USAGE INFORMATION
  19.            How to take:
  20.              Tablet or capsule--Swallow with liquid.  If you can't 
  21.              swallow whole, crumble tablet or open capsule and take 
  22.              with liquid or food.
  23.              
  24.            When to take:
  25.              At the same times each day.
  26.  
  27.            If you forget a dose:
  28.              Take as soon as you remember up to 2 hours late.  If 
  29.              more than 2 hours, wait for next scheduled dose (don't 
  30.              double this dose).
  31.              
  32.            What drug does:
  33.              Delays nerve impulses to heart to regulate heartbeat.
  34.              
  35.            Time lapse before drug works:
  36.              Begins in 30 to 60 minutes.  Must use for 5 to 7 days to 
  37.              determine effectiveness.
  38.              
  39.        POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
  40.            Symptoms                   What to do
  41.            Life-threatening:
  42.             None expected.
  43.             
  44.            Common:
  45.             Hypoglycemia               Discontinue.  Call doctor
  46.                                        right away.
  47.                                        
  48.             Dry mouth, constipation,   Continue.  Call doctor
  49.             painful or difficult       when convenient.
  50.             urination, rapid  
  51.             weight gain.
  52.             
  53.            Infrequent:
  54.             Dizziness, fainting,       Discontinue.  Call doctor
  55.             confusion, nervousness,    right away.
  56.             depression, chest pain,
  57.             slow or fast heartbeat.
  58.             
  59.             Swollen feet.              Continue.  Call doctor
  60.                                        when convenient.
  61.            
  62.            Rare:
  63.             Sore throat with           Discontinue.  Call doctor
  64.             fever, jaundice.           right away.
  65.             
  66.             Eye pain, diminished       Continue.  Call doctor
  67.             sex drive.                 when convenient.
  68.             
  69.        OVERDOSE
  70.            Symptoms:
  71.              Blood-pressure drop, irregular heartbeat.
  72.            What to do:
  73.              *Dial 0 (operator) or 911 (emergency) for an ambulance 
  74.               or medical help.  Then give first aid immediately.
  75.              *If patient is unconscious and not breathing, give 
  76.               mouth-to-mouth breathing.  If there is no heartbeat, use 
  77.               cardiac massage and mouth-to-mouth breathing (CPR). 
  78.               Don't try to make patient vomit.  If you can't get help 
  79.               quickly, take patient to nearest emergency facility.
  80.              *See emergency information.
  81.              
  82.        WARNINGS AND PRECAUTIONS
  83.            Don't take if:
  84.              You are allergic to disopyramide or any antiarrhythmic.
  85.              You have second- or third-degree heart block.
  86.              
  87.            Before you start, consult your doctor:
  88.              If you react unfavorably to other antiarrhythmic drugs.
  89.              If you have had heart disease.
  90.              If you have low blood pressure.
  91.              If you have liver disease.
  92.              If you have glaucoma.
  93.              If you have enlarged prostate.
  94.              If you have myasthenia gravis.
  95.              If you take digitalis preparations or diuretics.
  96.              
  97.            Over age 60:
  98.              May require reduced dose.
  99.              More likely to have difficulty urinating or be 
  100.              constipated.
  101.              More likely to have blood-pressure drop.
  102.              
  103.            Pregnancy:
  104.              No proven harm to unborn child.  Avoid if possible.
  105.              
  106.            Breast-feeding:
  107.              Drug passes into milk.  Avoid drug or discontinue 
  108.              nursing until you finish medicine.  Consult doctor for 
  109.              advice on maintaining milk supply.
  110.              
  111.            Infants and children:
  112.              Safety not established.  Don't use.
  113.              
  114.            Prolonged use:
  115.              No problems expected.
  116.              
  117.            Skin and sunlight:
  118.              No problems expected.
  119.              
  120.            Driving, piloting or hazardous work:
  121.              Don't drive or pilot aircraft until you learn how 
  122.              medicine affects  you.  Don't work around dangerous 
  123.              machinery.  Don't climb ladders or work in high places. 
  124.              Danger increases if you drink alcohol or take medicine 
  125.              affecting alertness and reflexes, such as 
  126.              antihistamines, tranquilizers, sedatives, pain 
  127.              medicine, narcotics, or mind-altering drugs.
  128.            
  129.            Discontinuing:
  130.              Don't discontinue without doctor's advice until you 
  131.              complete prescribed dose, even though symptoms diminish 
  132.              or disappear.
  133.              
  134.            Others:
  135.              If new illness, injury or surgery occurs, tell doctors 
  136.              of disopyramide use.
  137.              
  138.        POSSIBLE INTERACTION WITH OTHER DRUGS
  139.            Generic Name or Drug Class    Combined Effect
  140.             Ambenonium                    Decreased ambenonium
  141.                                           effect.
  142.                                           
  143.             Anticholinergics              Increased anticholinergic
  144.                                           effect.
  145.                                           
  146.             Anticoagulants (oral)         Increased anticoagulant
  147.                                           effect.
  148.                                           
  149.             Antihypertensives             Increased antihypertensive
  150.                                           effect.
  151.                                           
  152.             Antimyasthenics               Decreased antimyasthenic
  153.                                           effect.
  154.                                           
  155.             Flecainide                    Possible irregular 
  156.                                           heartbeat.
  157.                                           
  158.             Tocainide                     Increased likelihood of
  159.                                           adverse reactions with 
  160.                                           either drug.
  161.                                           
  162.        POSSIBLE INTERACTION WITH OTHER SUBSTANCES
  163.            Interacts With                Combined Effect
  164.             Alcohol                       Decreased blood pressure
  165.                                           and blood sugar.  Use 
  166.                                           caution.
  167.                                           
  168.             Beverages                     None expected.
  169.             
  170.             Cocaine                       Irregular heartbeat.
  171.             
  172.             Foods                         None expected.
  173.             
  174.             Marijuana                     Unpredictable.  May 
  175.                                           decrease disopyramide
  176.                                           effect.
  177.                                           
  178.             Tobacco                       May decrease disopyramide
  179.                                           effect.
  180.  
  181.  
  182.  
  183.  
  184.  
  185.  
  186.  
  187.        PROPRANOLOL
  188.  
  189. BRAND NAMES
  190.  
  191.     Apo-Propranolol                Inderide
  192.     Detensol                       Novopranol
  193.     Inderal                        Panolol
  194.     Inderal LA                     pms-Propranolol
  195.     
  196. BASIC INFORMATION
  197.  
  198.     Habit forming?   No
  199.     Prescription needed?  Yes
  200.     Available as generic? Yes
  201.     Drug class: Beta-adrenergic blocker
  202.     
  203. USES
  204.  
  205.     .Reduces angina attacks.
  206.     .Stabilizes irregular heartbeat.
  207.     .Lowers blood pressure.
  208.     .Reduces frequency of migraine headaches.
  209.      (Does not relieve headache pain.)
  210.     .Other uses prescribed by your doctor.
  211.     
  212. DOSAGE & USAGE INFORMATION
  213.     
  214.     How to take:
  215.         Tablet, liquid or extended-release capsule--Swallow with 
  216.         liquid. If you can't swallow whole, crumble tablet or open 
  217.         capsule and take with liquid or food. Don't crush capsule.
  218.         
  219.     When to take:
  220.         With meals or immediately after.
  221.         
  222.     If you forget a dose:
  223.         Take as soon as you remember. Return to regular schedule, but 
  224.         allow 3 hours between doses.
  225.         
  226.     What drug does:
  227.         .Blocks certain actions of sympathetic nervous system.
  228.         .Lowers heart's oxygen requirements.
  229.         .Slows nerve impulses through heart.
  230.         .Reduces blood vessel contraction in heart, scalp and other 
  231.          body parts.
  232.  
  233.     Time lapse before drug works:
  234.         1 to 4 hours.
  235.         
  236.     Don't take with:
  237.         Non-prescription drugs or drugs in interaction column without 
  238.         consulting doctor.
  239.         
  240. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
  241.  
  242.     Symptoms                         What to do
  243.     ___________________________________________________________________
  244.     Life-threatening:
  245.       Congestive heart failure.      Discontinue. Seek emergency
  246.                                      treatment.
  247.     
  248.     Common:
  249.       .Pulse slower than 50          Discontinue. Call doctor
  250.        beats per minute.             right away.
  251.       .Drowsiness, fatigue,          Continue. Call doctor
  252.        numbness or tingling          when convenient.
  253.        of fingers or toes,
  254.        dizziness, diarrhea,
  255.        nausea, weakness.
  256.       .Cold hands or feet;           Continue. Tell doctor
  257.        dry mouth, eyes and           at next visit.
  258.        skin.
  259.     
  260.     Infrequent:
  261.       .Hallucinations,               Discontinue. Call doctor
  262.        nightmares, insomnia,         right away.
  263.        headache, difficult
  264.        breathing, joint pain,
  265.        anxiety.
  266.       .Confusion, reduced            Continue. Call doctor when
  267.        alertness, depression,        convenient.
  268.        impotence.
  269.       .Constipation.                 Continue. Tell doctor at 
  270.                                      next visit.
  271.     
  272.     Rare:
  273.       .Rash, sore throat,            Discontinue. Call doctor
  274.        fever.                        right away.
  275.       .Unusual bleeding and          Continue. Call doctor when
  276.        bruising; dry, burning        convenient.
  277.        eyes; impotence.
  278.   
  279. OVERDOSE
  280.     Symptoms:
  281.       Weakness, slow or weak pulse, blood-pressure drop, fainting,
  282.       difficulty breathing, convulsions, cold and sweaty skin.
  283.     
  284.     What to Do:
  285.       .Dial 0 (operator) or 911 (emergency) for an ambulance or
  286.        medical help. Then give first aid immediately.
  287.       .See emergency information.
  288.       
  289. WARNINGS AND PRECAUTIONS
  290.     Don't take if:
  291.       .You are allergic to any beta-adrenergic blocker.
  292.       .You have asthma.
  293.       .You have hay fever symptoms.
  294.       .You have taken MAO inhibitors in past 2 weeks.
  295.       
  296.     Before you start, consult your doctor:
  297.       .If you have heart disease or poor circulation to the 
  298.        extremities.
  299.       .If you have hay fever, asthma, chronic bronchitis, emphysema.
  300.       .If you have overactive thyroid function.
  301.       .If you have impaired liver or kidney function.
  302.       .If you will have surgery within 2 months, including dental
  303.        surgery, requiring general or spinal anesthesia.
  304.       .If you have diabetes or hypoglycemia.
  305.       
  306.     Over age 60:
  307.       Adverse reactions and side effects may b emore frequent and 
  308.       severe than in younger persons.
  309.       
  310.     Pregnancy:
  311.       Risk to unborn child outweighs drug benefits. Don't use.
  312.       
  313.     Breast-feeding:
  314.       Drug passes into milk. Avoid drug or discontinue nursing 
  315.       until you finish medicine. Consult doctor for advice on 
  316.       maintaining milk supply.
  317.       
  318.     Infants and children:
  319.       Not recommended.
  320.       
  321.     Prolonged use:
  322.       Weakens heart muscle contractions.
  323.       
  324.     Skin and sunlight:
  325.       No problems expected.
  326.       
  327.     Driving, piloting or hazardous work:
  328.       Don't drive or pilot aircraft until you learn how medicine
  329.       affects you. Don't work around dangerous machinery. Don't climb 
  330.       ladders or work in high places. Danger increases if you drink
  331.       alcohol or take medicine affecting alertness and reflexes.
  332.       
  333.     Discontinuing:
  334.       Don't discontinue without consulting doctor. Dose may require
  335.       gradual reduction if you have taken drug for a long time.
  336.       Doses of other drugs may also require adjustment.
  337.       
  338.     Others:
  339.       May mask hypoglycemia.
  340.       
  341. POSSIBLE INTERACTION WITH OTHER DRUGS
  342.  
  343. Generic Name or Drug Class           Combined Effect
  344. _______________________________________________________________________
  345. ACE inhibitors:                      Increased antihypertensive
  346. captopril, enalapril,                effects of both drugs. 
  347. lisinopril                           Dosages may require adjustment.
  348.  
  349. Antidiabetics                        Increased antidiabetic effect.
  350.  
  351. Antihistamines                       Decreased antihistamine effect.
  352.  
  353. Antihypertensives                    Increased antihypertensive effect.
  354.  
  355. Barbiturates                         Increased barbiturate effect. 
  356.                                      Dangerous sedation.
  357.  
  358. Beta-agonists                        Decreased beta-agonist effect.
  359.  
  360. Betaxolol eyedrops                   Possible increased propronalol
  361.                                      effect.
  362.                                      
  363. Digitalis preparations               Can either increase or decrease
  364.                                      heart rate. Improves irregular
  365.                                      heartbeat.
  366.                                      
  367. Encainide                            Increased effect of toxicity on 
  368.                                      heart muscle.
  369.  
  370. Indomethacin                         Decreased effect of propranolol.
  371.  
  372. Insulin                              Hypoglycemic effects may be prolonged.
  373.  
  374. Levobunolol eyedrops                 Possible increased propranolol effect.
  375.  
  376. Molindone                            Increased tranquilizer effect.
  377.  
  378. Narcotics                            Increased narcotic effect. 
  379.                                      Dangerous sedation.
  380.  
  381. Nitrates                             Possible excessive blood-pressure drop.
  382.  
  383. Non-steroidal                        Decreased antihypertensive effect
  384. anti-inflammatory                    of propranolol.
  385. drugs (NSAIDS)
  386.  
  387. Phenytoin                            Decreased propranolol effect.
  388.  
  389. Quinidine                            Slows heart excessively.
  390.  
  391. Reserpine                            Increased reserpine effect.
  392.                                      Excessive sedation and depression.
  393.                                      
  394. Rifampin                             Decreased propranolol effect.
  395.  
  396. Timolol eyedrops                     Possible increased propranolol
  397.                                      effect.
  398.  
  399. Tocainide                            May worsen congestive heart
  400.                                      failure.
  401.  
  402. Verapamil                            Increased effect of both drugs.
  403. _______________________________________________________________________
  404.  
  405. POSSIBLE INTERACTION WITH OTHER SUBSTANCES
  406.  
  407. Interacts with                       Combined effect
  408. _______________________________________________________________________
  409. Alcohol                              Excessive blood-pressure drop.
  410.                                      Avoid.
  411.  
  412. Beverages                            None expected.
  413.  
  414. Cocaine                              Irregular heartbeat. Avoid.
  415.  
  416. Foods                                None expected.
  417.  
  418. Marijuana                            Daily use--impaired circulation
  419.                                      to hands and feet.
  420.  
  421. Tobacco                              Possible irregular heartbeat.
  422.  
  423.  
  424.  
  425.  
  426.  
  427.                              ISOXSUPRINE
  428.  
  429.        BRAND NAMES
  430.            Vasodilan         Vasoprine
  431.            
  432.        BASIC INFORMATION
  433.            Habit forming?  No
  434.            Prescription needed?  Yes
  435.            Available as generic?  Yes
  436.            Drug class:  Vasodilator
  437.        
  438.        USES
  439.            Improves poor blood circulation.
  440.            
  441.        DOSAGE AN USAGE INFORMATION
  442.            How to take:
  443.              Tablet--Swallow with liquid or food to lessen stomach 
  444.              irritation.  If you can't swallow whole, crumble tablet 
  445.              and take with liquid or food.
  446.              
  447.            When to take:
  448.              At the same times each day.
  449.              
  450.            If you forget a dose:
  451.              Take as soon as you remember up to 2 hours late.  If 
  452.              more than 2 hours, wait for next scheduled dose (don't 
  453.              double this dose).
  454.              
  455.            What drug does:
  456.              Expands blood vessels, increasing flow and permitting 
  457.              distribution of oxygen and nutrients.
  458.              
  459.            Time lapse before drug works:
  460.              1 hour.
  461.              
  462.        POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
  463.            Symptoms                      What To Do
  464.            Life-threatening:
  465.              None expected.
  466.              
  467.            Common:
  468.              Appetite loss, nausea,      Discontinue.  Call doctor
  469.              vomiting.                   right away.
  470.              
  471.              Dizziness, faintness.       Continue.  Call doctor
  472.                                          when convenient.
  473.                                          
  474.              Weakness, lethargy.         Continue.  Tell doctor
  475.                                          at next visit.
  476.                                          
  477.            Infrequent:
  478.              Rash.                       Discontinue.  Call doctor
  479.                                          right away.
  480.                                          
  481.            Rare:
  482.              Rapid or irregular          Discontinue.  Call doctor
  483.              heartbeat.                  right away.
  484.              
  485.        OVERDOSE
  486.            Symptoms:
  487.              Headache, dizziness, flush, vomiting, weakness, 
  488.              sweating, fainting, shortness of breath, coma.
  489.              
  490.            What to do:
  491.              Dial 0 (operator) or 911 (emergency) for an ambulance 
  492.              or medical help.  Then give first aid immediately.
  493.              
  494.              If patient is unconscious and not breathing, give 
  495.              mouth-to-mouth breathing.  If there is no heartbeat, use 
  496.              cardiac massage and mouth-to-mouth breathing (CPR). 
  497.              Don't try to make patient vomit.  If you can't get help 
  498.              quickly, take patient to nearest emergency facility.
  499.               
  500.              See emergency information.
  501.              
  502.        WARNINGS AND PRECAUTIONS
  503.            Don't take if:
  504.              You are allergic to any vasodilator.
  505.              You have any bleeding disease.
  506.              
  507.            Before you start, consult your doctor:
  508.              If you have high blood pressure, hardening of the 
  509.              arteries or heart disease.
  510.              
  511.              If you plan to become pregnant within medication period.
  512.              
  513.              If you have glaucoma.
  514.              
  515.            Over age 60:
  516.              Adverse reactions and side effects may be more frequent 
  517.              and severe than in younger persons.
  518.              
  519.            Pregnancy:
  520.              Studies inconclusive on harm to unborn child.  Decide 
  521.              with your doctor whether drug benefits justify risk to 
  522.              unborn child.
  523.              
  524.            Breast-feeding:
  525.              No problems expected, but consult doctor.
  526.              
  527.            Infants and children:
  528.              Not recommended.
  529.              
  530.            Prolonged use:
  531.              No problems expected.
  532.              
  533.            Skin and sunlight:
  534.              No problems expected,
  535.              
  536.            Driving, piloting or hazardous work:
  537.              Avoid if you feel dizzy or faint.  Otherwise, no 
  538.              problems expected.
  539.              
  540.            Discontinuing:
  541.              Don't discontinue without doctor's advice until you 
  542.              complete prescribed dose, even though symptoms diminish 
  543.              or disappear.
  544.              
  545.            Others:
  546.              Be cautious when arising from lying or sitting position, 
  547.              when climbing stairs, or if dizziness occurs.
  548.              
  549.        POSSIBLE INTERACTION WITH OTHER DRUGS
  550.            Generic Name or Drug Class        Combined Effect
  551.              None
  552.              
  553.        POSSIBLE INTERACTION WITH OTHER SUBSTANCES
  554.            Interacts With                 Combined Effect
  555.              Alcohol                        None expected.
  556.              
  557.              Beverages                      Decreased stomach
  558.                Milk                         irritation.
  559.                
  560.              Cocaine                        Decreased blood 
  561.                                             circulation to 
  562.                                             extremities.  Avoid.
  563.                                             
  564.              Foods                          None expected.
  565.              
  566.              Marijuana                      Rapid heartbeat.
  567.              
  568.              Tobacco                        Decreased isoxsuprine
  569.                                             effect.
  570.  
  571.  
  572.  
  573.  
  574.  
  575.  
  576.                               NITRATES
  577.  
  578.        BRAND NAMES:
  579.           Ang-O-Span, Cardilate, Coronex, Dilatrate-SR, Duotrate,
  580.           
  581.           The following are listed under their generic names (in 
  582.           capitals).
  583.           
  584.          ERYTHRITYL TETRANITRATE         ISOSORBIDE DINITRATE
  585.            Glyceryl Trinitrate             Isotrate
  586.            Iso-Bid                         Kaytrate
  587.            Isochron                        Klavikordal
  588.            Isogard                         Naptrate
  589.            Isonate                         N-G-C
  590.            Isonate TR                      Niong
  591.            Isordil                         Nitro-Bid
  592.                                            Nitrobon
  593.          NITROGLYCERIN                     Nitrocap
  594.            Nitroglyn                       Nitrocap T.D.
  595.            Nitrol                          Nitrocardin
  596.            Nitrolin                        Nitrodisc
  597.            Nitro-Long                      Nitro-Dur
  598.            Nitronet                        Nitrogard-SR
  599.            Nitrong
  600.            Nitrospan                                                  
  601.            Nitrostablin                           
  602.            Nitrostat      
  603.            Nitro-Time           
  604.            Novosorbide          
  605.            Onset    
  606.       
  607.          PENTAERYTHRITOL TETRANITRATE
  608.            Pentestan     
  609.            Pentol   
  610.            Pentol S.A.                           
  611.            Pentraspan             
  612.            Pentraspan SR
  613.            Pentritol
  614.            Pentylan
  615.            Peritrate
  616.            Peritrate SA
  617.            P.E.T.N.
  618.            Sorate
  619.            Sorbide
  620.            Sorbide T.D.
  621.            Sorbitrate
  622.            Sorbitrate SA
  623.            Susadrin
  624.            Tranderm-Nitro
  625.            Trates
  626.            Tridil
  627.            Vaso-80
  628.            Vasoglyn
  629.   
  630.        BASIC INFORMATION
  631.            Habit forming?  No
  632.            Prescription needed?  Yes
  633.            Available as generic?  Yes
  634.            Drug class:  Antianginal (nitrate)
  635.            
  636.        USES
  637.            Reduces frequency and severity of angina attacks.
  638.            
  639.        DOSAGE AND USAGE INFORMATION
  640.            How to take:
  641.              *Extended-release tablets or capsules
  642.                 Swallow each dose whole with liquid.
  643.              *Chewable tablet
  644.                 Chew tablet at earliest sign of angina, and hold in 
  645.                 mouth for 2 minutes.
  646.              *Regular tablet or capsule
  647.                 Swallow whole with liquid.  Don't crush, chew or 
  648.                 open.
  649.              *Ointment
  650.                 Apply as directed.
  651.              *Sublingual tablets
  652.                 Place under tongue every 3 to 5 minutes at earliest 
  653.                 sign of angina.  If you don't have complete relief 
  654.                 with 3 or 4 tablets, call doctor.
  655.            
  656.            When to take:
  657.               *Swallowed tablets
  658.                  Take at the same times each day, 1 or 2 hours after 
  659.                  meals.
  660.               *Ointment
  661.                  Follow prescription directions.
  662.            
  663.            If you forget a dose:
  664.               Take as soon as you remember up to 2 hours late.  If 
  665.               more than 2 hours, wait for next scheduled dose (don't 
  666.               double this dose).
  667.            
  668.            What drug does:
  669.               Relaxes blood vessels, increasing blood flow to heart 
  670.               muscle.
  671.               
  672.            Time lapse before drug works:
  673.               *Sublingual tablets
  674.                  1 to 3 minutes.
  675.               *Other forms
  676.                  15 to 30 minutes.  Will not stop an attack, but may 
  677.                  prevent attacks.
  678.        
  679.        OVERDOSE
  680.           Symptoms:
  681.              Dizziness; blue fingernails and lips; fainting; 
  682.              shortness of breath; weak, fast heartbeat; convulsions.
  683.           What to do:
  684.              *Dial 0 (operator) or 911 (emergency) for an ambulance 
  685.              or medical help.  Then give first aid immediately.
  686.              *See section on emergency information.
  687.              
  688.        POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
  689.           Symptoms                        What to do
  690.           Life-threatening:
  691.             None expected.
  692.             
  693.           Common:
  694.             Headache, flushed             Continue.  Tell doctor
  695.             face and neck, dry            at next visit.
  696.             mouth, nausea, vomiting, 
  697.             rapid heartbeat.
  698.             
  699.           Infrequent:
  700.             Fainting                      Discontinue.  Call doctor
  701.                                           right away.
  702.             Restlessness,                 Continue.  Call doctor
  703.             Blurred vision.               when convenient.
  704.             
  705.           Rare:
  706.             Rash                          Discontinue. Call doctor
  707.                                           right away.
  708.             Severe irritation,            Continue. Call doctor
  709.             peeling.                      when convenient.
  710.             
  711.        WARNINGS AND PRECAUTIONS
  712.            Don't take if:
  713.               You are allergic to nitrates, including nitroglycerin.
  714.               
  715.            Before you start, consult your doctor:
  716.               If you are taking non-prescription drugs.
  717.               If you plan to become pregnant within medication 
  718.               period.
  719.               If you have glaucoma.
  720.               If you have reacted badly to any vasodilator drug.
  721.               If you drink alcoholic beverages or smoke marijuana.
  722.               
  723.            Over age 60:
  724.               Adverse reactions and side effects may be more frequent 
  725.               and severe than in younger persons.
  726.               
  727.            Pregnancy:
  728.               No proven harm to unborn child.  Avoid if possible.
  729.               
  730.            Breast-feeding:
  731.               No problems expected.  Consult your doctor.
  732.               
  733.            Infants and children:
  734.               Not recommended.
  735.               
  736.            Prolonged use:
  737.               Drug may become less effective and require higher 
  738.               doses.
  739.               
  740.            Skin and sunlight:
  741.               No problems expected.
  742.               
  743.            Driving, piloting or hazardous work:
  744.               Don't drive or pilot aircraft until you learn how 
  745.               medicine affects you.  Don't work around dangerous 
  746.               machinery.  Don't climb ladders or work in high places. 
  747.               Danger increases if you drink alcohol or take medicine 
  748.               affecting alertness and reflexes.
  749.               
  750.            Discontinuing:
  751.               Except for sublingual tablets, don't discontinue 
  752.               without doctor's advice until you complete prescribed 
  753.               dose, even though symptoms diminish or disappear.
  754.               
  755.            Others:
  756.               If discomfort is not caused by angina, nitrate 
  757.               medication will not bring relief. Call doctor id 
  758.               discomfort persists.
  759.               Periodic urine and laboratory blood studies of white 
  760.               cell counts recommended if you take nitrates.
  761.               Keep sublingual tablets in original container. Always 
  762.               carry them with you, but keep from body heat if 
  763.               possible.
  764.               
  765.        POSSIBLE INTERACTION WITH OTHER DRUGS
  766.           Generic Name or Drug Class   Combined Effect
  767.             Anticholinergics            Increased internal-eye
  768.                                         pressure.
  769.             
  770.             Antidepressants             Excessive blood-pressure
  771.              (tricyclics)               drop.
  772.              
  773.             Antihypertensives           Excessive blood-pressure
  774.                                         drop.
  775.                                         
  776.             Cholinergics                Decreased cholinergic effect.
  777.             
  778.             Ephedrine                   Decreased nitrate effect.
  779.             
  780.             Labetolol                   Increased antihypertensive
  781.                                         effects.
  782.                                         
  783.             Narcotics                   Excessive blood-pressure drop
  784.             
  785.             
  786.        POSSIBLE INTERACTION WITH OTHER SUBSTANCES
  787.           Interacts With               Combined Effect
  788.            Alcohol                      Excessive blood-pressure drop
  789.            
  790.            Beverages                    None expected.
  791.            
  792.            Cocaine                      Flushed face and headache.
  793.                                         Avoid.
  794.                                         
  795.            Marijuana                    Decreased nitrate effect.
  796.            
  797.            Tobacco                      Decreased nitrate effect.
  798.  
  799.  
  800.  
  801.  
  802.  
  803.  
  804.                                 NIFEDIPINE    
  805.  
  806. BRAND NAMES
  807.  
  808.     Adalat
  809.     Procardia
  810.     
  811. BASIC INFORMATION
  812.  
  813.     Habit forming?  No
  814.     Prescription needed? Yes
  815.     Available as generic? No
  816.     Drug class: Calcium-channel blocker, antiarrhythmic, antianginal.
  817.     
  818. USES
  819.     
  820.     .Prevents angina attacks.
  821.     .Treats Reynaud's disease.
  822.     .Treats high blood pressure.
  823.     .Treats spasm of the esophagus.
  824.     
  825. DOSAGE AND USAGE INFORMATION
  826.  
  827.     How to take:
  828.       Capsule or extended-release tablet--Swallow with liquid.
  829.       
  830.     When to take:
  831.       At the same times each day 1 hour before or 2 hours after 
  832.       eating.
  833.       
  834.     If you forget a dose:
  835.       Take as soon as you remember up to 2 hours late. If more than 2 
  836.       hours, wait for next scheduled dose (don't double this dose).
  837.       
  838.     What drug does:
  839.       .Reduces work that heart must perform.
  840.       .Reduces normal artery pressure.
  841.       .Increases oxygen to heart muscle.
  842.       
  843.     Time lapse before drug works:
  844.       1 to 2 hours.
  845.       
  846.     Don't take with:
  847.       See Interaction column and consult doctor.
  848.       
  849. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
  850.  
  851.     Symptoms                           What To Do
  852. _______________________________________________________________________
  853. Life-threatening:
  854.   None expected.
  855.   
  856. Common:
  857.   Tiredness, flushing,                 Continue. Tell doctor
  858.   swelling of feet,                    at next visit.
  859.   ankles and abdomen.
  860.   
  861. Infrequent:
  862.   .Unusually fast or                   Discontinue. Call
  863.    unusually slow                      doctor right away.
  864.    heartbeat, wheezing,
  865.    cough, shortness of
  866.    breath.
  867.   .Dizziness; numbness                 Continue. Call doctor
  868.    or tingling in hands                when convenient.
  869.    or feet; swelling of
  870.    ankles, feet, legs;
  871.    difficult urination.
  872.   .Nausea                              Continue. Tell doctor
  873.    constipation.                       at next visit.
  874.    
  875. Rare:
  876.   .Transient blindness,                Discontinue. Seek
  877.    increased angina.                   emergency treatment.
  878.   .Fainting, chest pain,               Discontinue. Call
  879.    fever, rash, jaundice,              doctor right away.
  880.    depression, psychosis.
  881.   .Arthritis, hair loss.               Continue. Call doctor
  882.    vivid dreams.                       when convenient.
  883.   .Headache.                           Continue. Tell doctor
  884.                                        at next visit.
  885.  
  886. OVERDOSE
  887.  
  888.     Symptoms:
  889.       Unusually fast or unusually slow heartbeat, loss of 
  890.       consciousness, cardiac arrest.
  891.       
  892.     What to do:
  893.       .Dial 0 (operator) or 911 (emergency) for an ambulance or 
  894.        medical help. Then give first aid immediately.
  895.       .If patient is unconscious and not breathing, give 
  896.        mouth-to-mouth breathing. If there is no heartbeat, use 
  897.        cardiac massage and mouth-to-mouth breathing (CPR). Don't try 
  898.        to make patient vomit. If you can't get help quickly, take 
  899.        patient to nearest emergency facility.
  900.       .See emergency information.
  901.  
  902. WARNINGS AND PRECAUTIONS
  903.  
  904.     Don't take if:
  905.       .You are allergic to nifedipine.
  906.       .You have very low blood pressure.
  907.       
  908.     Before you start, consult your doctor:
  909.       .If you have kidney or liver disease.
  910.       .If you have high blood pressure.
  911.       .If you have heart disease other than coronary-artery disease.
  912.       
  913.     Over age 60:
  914.       Adverse reactions and side effects may be more frequent and 
  915.       severe than in younger persons.
  916.       
  917.     Pregnancy:
  918.       No proven harm to unborn child. Avoid if possible.
  919.       
  920.     Breast-feeding:
  921.       Safety not established. Avoid if possible.
  922.       
  923.     Infants and children:
  924.       Not recommended.
  925.       
  926.     Prolonged use:
  927.       No problems expected.
  928.       
  929.     Skin and sunlight:
  930.       Increased sensitivity to sunlight.
  931.       
  932.     Driving, piloting or hazardous work:
  933.       Avoid if you feel dizzy. Otherwise, no problems expected.
  934.       
  935.     Discontinuing:
  936.       Don't discontinue without doctor's advice until you complete 
  937.       prescribed dose, even though symptoms diminish or disappear.
  938.       
  939.     Others:
  940.       .Learn to check your own pulse rate. If it drops to 50 beats 
  941.        per minute or lower, don't take nifedipine until you consult 
  942.        your doctor.
  943.       .Drug may lower blood-sugar level if daily dose is more than 60 
  944.        mg.
  945.       
  946. POSSIBLE INTERACTION WITH OTHER DRUGS
  947.  
  948. Generic Name or Drug Class             Combined effect
  949. _______________________________________________________________________
  950. ACE inhibitors:                        Possible excessive
  951. captopril, enalapril,                  potassium in blood.
  952. lisinopril                             Dosages may need adjustment.
  953.  
  954. Antiarrhythmics                        Possible increased effect and
  955.                                        toxicity of each drug.
  956.                                        
  957. Anticoagulants                         Possible increased 
  958. (oral)                                 anticoagulant effect.
  959.  
  960. Anticonvulsants                        Increased
  961. (hydantoin)                            anticonvulsant effect.
  962.  
  963. Antihypertensives                      Dangerous blood pressure
  964.                                        drop. Dosage may need adjustment.
  965.                                        
  966. Beta-adrenergic                        Possible irregular heartbeat.
  967. blockers                               May worsen congestive heart
  968.                                        failure.
  969.  
  970. Calcium                                Possible decreased nifedipine
  971. (large doses)                          effect.
  972.  
  973. Carbamazepine                          May increase carbamazepine
  974.                                        effect and toxicity.
  975.  
  976. Cimetidine                             Possible increased nifedipine
  977.                                        effect and toxicity.
  978.                                        
  979. Disopyramide                           May cause dangerously slow,
  980.                                        fast or irregular heartbeat.
  981.                                        
  982. Diuretics                              Dangerous blood pressure drop.
  983.  
  984. Lithium                                Possible decreased lithium effect.
  985.  
  986. Nitrates                               Reduced angina attacks.
  987.  
  988. Phenytoin                              Possible decreased nifedipine
  989.                                        effect.
  990.                                        
  991. Quinidine                              Increased quinidine effect.
  992.  
  993. Rifampin                               Decreased nifedipine effect.
  994.  
  995. Theophylline                           May increase theophylline
  996.                                        effect and toxicity.
  997.                                        
  998. Tocainide                              Increased likelihood of adverse
  999.                                        reactions from either drug.
  1000.  
  1001. Vitamin D                              Decreased nifedipine effect.
  1002. (large doses)
  1003. _______________________________________________________________________
  1004.  
  1005. POSSIBLE INTERACTION WITH OTHER SUBSTANCES
  1006.  
  1007. Interacts with                         Combined effect
  1008. _______________________________________________________________________
  1009. Alcohol:                               Dangerously low blood pressure.
  1010.                                        Avoid.
  1011.                                        
  1012. Beverages:                             None expected.
  1013.  
  1014. Cocaine:                               Possible irregular heartbeat.
  1015.                                        Avoid.
  1016.                                        
  1017. Foods:                                 None expected.
  1018.  
  1019. Marijuana:                             Possible irregular heartbeat.
  1020.                                        Avoid.
  1021.                                        
  1022. Tobacco:                               Possible rapid heartbeat. Avoid.
  1023.  
  1024.  
  1025.  
  1026.  
  1027.  
  1028.  
  1029.                              METHYSERGIDE
  1030.  
  1031. BRAND NAMES
  1032.  
  1033.     Sansert
  1034.     
  1035. BASIC INFORMATION
  1036.  
  1037.     Habit forming?  Yes
  1038.     Prescription needed? Yes
  1039.     Available as generic? No
  1040.     Drug class: Vasoconstrictor (antiserotonin)
  1041.     
  1042. USES
  1043.     Prevents migraine and other recurring vascular headaches. Not for 
  1044.     acute attack.
  1045.     
  1046. DOSAGE AND USAGE INFORMATION
  1047.     How to take:
  1048.       Tablet--Swallow with liquid or with food to lessen stomach 
  1049.       irritation. If you can't swallow whole, crumble tablet and take 
  1050.       with liquid or food.
  1051.       
  1052.     When to take:
  1053.       At the same times each day.
  1054.       
  1055.     If you forget a dose:
  1056.       Don't take missed dose. Wait for next scheduled dose (DON'T 
  1057.       double this dose).
  1058.       
  1059.     What drug does:
  1060.       Blocks the action of serotonin, a chemical that constricts 
  1061.       blood vessels.
  1062.       
  1063.     Time lapse before drug works:
  1064.       About 3 weeks.
  1065.       
  1066.     Don't take with:
  1067.       See interaction column and consult doctor.
  1068.       
  1069. POSSIBLE ADVERSE REACTIONS OR SIDE EFFECTS
  1070.  
  1071. Symptoms                             What to do
  1072. _________________________________________________________________________
  1073. Life-threatening:
  1074.   None expected       
  1075.   
  1076. Common:
  1077.   .Itchy skin.                       Discontinue. Call doctor right away.
  1078.   .Nausea, vomiting,                 Continue. Call doctor when
  1079.    diarrhea, numbness                convenient.
  1080.    or tingling of
  1081.    extremities.
  1082.   .Drowsiness,                       Continue. Tell doctor at next visit.
  1083.    constipation.
  1084.    
  1085. Infrequent:
  1086.   .Anxiety, agitation,               Discontinue. Call doctor right away.
  1087.    hallucinations,
  1088.    unusually fast or
  1089.    slow heartbeat.
  1090.   .Change in vision.                 Continue. Call doctor when convenient.
  1091.   
  1092. Rare:
  1093.   .Extreme thirst, chest             Discontinue. Call doctor right away.
  1094.    pain, shortness of
  1095.    breath, fever, pale
  1096.    or swollen extremities,
  1097.    leg cramps, lower back
  1098.    pain, side or groin pain.
  1099.    appetite loss, joint
  1100.    and muscle pain, rash,
  1101.    facial flush.
  1102.   .Painful or difficult              Continue. Call doctor when convenient.
  1103.    urination.
  1104.   .Weight change,                    Continue. Tell doctor at next visit.
  1105.    hair loss, swollen
  1106.    feet and ankles.
  1107. _____________________________________________________________________________
  1108. OVERDOSE
  1109.  
  1110.     Symptoms:
  1111.       Nausea, vomiting, abdominal pain, severe diarrhea, lack of 
  1112.       coordination, extreme thirst.
  1113.     
  1114.     What to do:
  1115.       Overdose unlikely to threaten life. If person takes much larger 
  1116.       amount than prescribed, call doctor, poison-control center or
  1117.       hospital emergency room for instructions.
  1118.       
  1119. WARNINGS AND PRECAUTIONS
  1120.     Don't take if:
  1121.       .You are allergic to any antiserotonin.
  1122.       .You plan to become pregnant within medication period.
  1123.       .You have an infection.
  1124.       .You have a heart or blood-vessel disease.
  1125.       .You have a chronic lung disease.
  1126.       .You have a collagen (connective tissue) disorder.
  1127.       .You have impaired liver or kidney function.
  1128.       
  1129.     Before you start, consult your doctor:
  1130.       .If you have been allergic to any ergot preparation.
  1131.       .If you have had a peptic ulcer.
  1132.       
  1133.     Over age 60:
  1134.       Adverse reactions and side effects may be more frequent and
  1135.       severe than in younger persons.
  1136.       
  1137.     Pregnancy:
  1138.       Manufacturer suggests risk to unborn child outweighs drug
  1139.       benefits, even though studies are inconclusive.
  1140.       
  1141.     Breast-feeding:
  1142.       Drug probably passes into milk. Avoid drug or discontinue 
  1143.       nursing until you finish medicine. Consult doctor for 
  1144.       advice on maintaining milk supply.
  1145.       
  1146.     Infants and children:
  1147.       Not recommended.
  1148.       
  1149.     Prolonged use:
  1150.       Possible fibrosis, a condition in which scar tissue is 
  1151.       deposited on heart valves, in lung tissue, blood vessels
  1152.       and internal organs. After 6 months, decrease dose over 2
  1153.       to 3 weeks. Then discontinue for at least 2 months for re-
  1154.       evaluation.
  1155.     
  1156.     Skin and sunlight:
  1157.       No problems expected.
  1158.       
  1159.     Driving, piloting or hazardous work:
  1160.       Avoid if you feel drowsy or dizzy.  Otherwise, no problems
  1161.       expected.
  1162.       
  1163.     Discontinuing:
  1164.       .Don't discontinue without consulting doctor.  Dose may 
  1165.        require gradual reduction if you have taken drug for a
  1166.        long time. doses of other drugs may also require adjustment.
  1167.       .Probably should discontinue drug if you don't improve after 
  1168.        3 weeks' use.
  1169.  
  1170.     Others:
  1171.       .Periodic laboratory tests for liver function and blood
  1172.        counts recommended.
  1173.       .Potential for abuse.
  1174.       .Some products contain tartrazine dye. Avoid, especially
  1175.        if you are allergic to aspirin.
  1176.  
  1177. POSSIBLE INTERACTION WITH OTHER DRUGS
  1178.  
  1179. Generic Name or Drug Class           Combined Effect
  1180. _________________________________________________________________________
  1181. Ergot Preparations                   Unpredictable increased or 
  1182.                                      decreased effect of either
  1183.                                      drug.
  1184. Narcotics                            Decreased narcotic effect.
  1185.  
  1186. POSSIBLE INTERACTION WITH OTHER SUBSTANCES
  1187.  
  1188. Interacts with                       Combined effect
  1189. _________________________________________________________________________
  1190. Alcohol:                             None expected. However, alcohol
  1191.                                      may trigger a migraine headache.
  1192.  
  1193. Beverages: 
  1194.   Caffeine drinks.                   Decreased methysergide effect.
  1195.  
  1196. Cocaine:                             May make headache worse.
  1197.  
  1198. Foods:                               None expected. Avoid foods to 
  1199.                                      which you are allergic.
  1200.  
  1201. Marijuana:                           No proven problems.
  1202.  
  1203. Tobacco:                             Blood-vessel constriction. Makes 
  1204.                                      headache worse.
  1205.                                      
  1206.  
  1207. Downloaded From P-80 International Information Systems 304-744-2253
  1208.