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- Posted-Date: Thu, 12 Nov 92 19:02:45 EST
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- Date: Thu, 12 Nov 1992 19:02:45 EST
- Sender: "Psychology Graduate Students Discussion Group List"
- <PSYCGRAD@UOTTAWA.BITNET>
- From: Eric Zorrilla <zorrilla@CATTELL.PSYCH.UPENN.EDU>
- Subject: Re: help with serotonin subtype binding
- In-Reply-To: <no.id>; from "@pucc.PRINCETON.EDU:PSYCGRAD@UOTTAWA.BITNET" at
- Nov 12, 92 1:01 pm
- Lines: 26
-
- > I'm in over my head on a lit review for neuropsych (topic:suicide). Can
- > anyone tell me if the subtypes for 5-HT receptors have functionally
- > different consequences?
-
- I can. Yes. Without question, they do.
-
- > For example, if there is an increase or decrease
- > in a particular region for 5-HT-subtype-1a binding site, does that indicate
- > that the entire serotonergic system is dysfunctional or that just that
- > subtype of 5-HT is dysfunctional?
-
- Dysfunctionalities can be isolated from one another. However, it's
- important to remember that 5-HT1a's act as negative feedback autoreceptors
- and post-synaptic receptors, so a change in binding sites is difficult to
- interpret in and of itself as increased or reduced transmission. You need to
- do stuff to modulate 5-HT synthesis to get a grip on what's going on.
-
- Still, different receptor subtypes *may*
- have functional consequences on other system subtypes (e.g., 5-HT1B autorecep-
- tors exist on 5HT secreting neurons that synapse with post-synaptic 5HT-1A
- receptors).
-
- An excellent review of this was recently written by Irwin Lucki here at
- Penn. (1992). I think it's a great place to start.
-
- Eric
-