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- Newsgroups: alt.psychoactives
- Path: sparky!uunet!mnemosyne.cs.du.edu!nyx!aankrom
- From: aankrom@nyx.cs.du.edu (Anthony Ankrom)
- Subject: Re: Ecstasy
- Message-ID: <1993Jan22.181434.6764@mnemosyne.cs.du.edu>
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- References: <21579@ucdavis.ucdavis.edu> <1993Jan22.073132.3739@news.yale.
- Date: Fri, 22 Jan 93 18:14:34 GMT
- Lines: 52
-
- In article <1993Jan22.073132.3739@news.yale.edu> FRICHARD@biomed.med.yale
- edu (Frank Richardson) writes:
- >In <21579@ucdavis.ucdavis.edu> ez018080@hamlet.ucdavis.edu writes:
- >
- >> of Ecstasy, E, X, or the chemical name MDMA methyl...something
- >> and the other FAQ is in the ftp site at u.washington/public/alt.drugs
- >> This site has many other FAQ's and info on many other drugs as well
- >> MDMA is almost like a truth serum. It is adrenergic and makes
- >> one talk a whole lot about anything that might happen to pop
- >> into ones head. It is not too clear yet whether or not it is
- >> neurotoxic, but if it is then not very much. I am no expert
- >
- >On the contrary, I would say that it is quite neurotoxic. Ecstacy causes
- a
- >profound release of the neurotrasmitter serotonin. It over stimulates th
- cells
- >so much they usually die. In rodents, as much as 80% of the serotonergic
- >neurons were lost. Recall, neurons in your brain generally DO NOT regene
- ate,
- >so once they're gone....Sorry if I sound like a cop, I'm not. Although i
- is
- >true that no precise studies have been done in humans, I wouldn't recomm
- nd X
- >for the time being.
- >Virtually,
- >myself
- >
- >####################################################################
- >Usual home of my sphere of consciousness: "I drank what?"
- >frichard@biomed.med.yale.edu -Attributed to
- >frichard@yalmed.bitnet Socrates,399B.C.
- >#####################################################################
-
-
- I have to beg to differ with the figures presented here by this poster. I
- would like to see reference citings, becuase the articles that I have read
- have NEVER reported the 80% loss in serotonergic neurons. I only regret
- that I cannot cite these references myself. If I recall, the neurotoxicity
- has to do with the serotonergic neurons taking up dopamine into the
- serotonergic neurons which somehow cannot properly metabolise it. I have
- heard that the potential for neurotoxicity of MDMA and PCA and
- fenfluramine can be reduced by taking a subtherapeutic dose of a sertonin
- uptake inhibitor, such as Prozac, as long as up to 6-8 hours after taking
- said drug(s). Taking the prozac can subdue the effects of the drug as
- well.
- One disparity that I have wondered about is whether or not the
- neurotoxicity that is being quoted is that of MDA or MDMA. They
- supposedly work in the brain via different mechanisms.It would seem odd
- that they would display similar neurotoxicities.
-
- St. Anthony
-
-