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- From: winalski@adserv.enet.dec.com (Paul S. Winalski)
- Subject: Re: Krebs cycle
- Message-ID: <1993Jan8.202652.8200@e2big.mko.dec.com>
- Lines: 18
- Sender: usenet@e2big.mko.dec.com (Mr. USENET)
- Reply-To: winalski@adserv.enet.dec.com (Paul S. Winalski)
- Organization: Digital Equipment Corporation, Nashua NH
- References: <726020993snz@lrts1.demon.co.uk> <1993Jan8.174736.11471@leland.Stanford.EDU>
- Date: Fri, 8 Jan 1993 20:26:52 GMT
-
-
- In article <1993Jan8.174736.11471@leland.Stanford.EDU>,
- kksng@leland.Stanford.EDU (Kenneth Kai-Sing Ng) writes:
- |>
- |>A second role of the TCA cycle is to generate, again from
- |>acetyl-CoA, four carbon building blocks for the synthesis of amino acids and
- |>glucose.
-
- Some microorganisms (particularly the cyanobacteria) are capable of running
- the TCA cycle backwards to generate pyruvate (and hence eventually glucose)
- from acetyl-CoA. This doesn't happen in most organisms, though. Man and I
- think all other mammals are incapable of net new glucose formation from
- acetyl-CoA. The seeds of plants, which are very active in such synthesis,
- don't do so using the TCA cycle. They use a shunt called the glyoxylate
- cycle. Most organisms lack two key enzymes necessary to run the glyoxylate
- pathway and thus generate new glucose from acetate.
-
- --PSW
-