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- Newsgroups: sci.med,connect.audit
- Path: sparky!uunet!elroy.jpl.nasa.gov!usc!sol.ctr.columbia.edu!eff!ibmpcug!kate.ibmpcug.co.uk!george
- From: george@ibmpcug.co.uk (Michael Veltman)
- Subject: Re: amnesiac drugs
- X-Disclaimer: The views expressed in this article are those of the author
- alone and may not represent the views of the IBM PC User Group.
- Organization: The IBM PC User Group, UK.
- Date: Sat, 25 Jul 1992 19:22:37 GMT
- Message-ID: <1992Jul25.192237.4136@ibmpcug.co.uk>
- References: <1992Jul24.114549.944@newstand.syr.edu>
- Sender: george@ibmpcug.co.uk (Michael Veltman)
- Lines: 69
-
- In article <1992Jul24.114549.944@newstand.syr.edu> mprisco@lynx.cat.syr.edu () writes:
- > Before they did it they told her they were going
- >to give her a drug so that she wouldn't remember it.
- > Anyway, what's the story with these
- >drugs? What was it, most likely? How do they work (not
- >too technical but what part of the brain or by what chemical
- >means or so they know?)? Is it possible that you might actually
- >remember the incident at some point?
- > Is it the kind of thing experienced
- >on a drug like Xanax? Do they do this alot?
- >Margot
-
-
- Dear Margot,
-
- Amnesia is casued by a large number of drugs, most of which
- are used by anaesthetists or physicians for procedures.
-
- The most potent amnestics are General anaesthetic agents,
- which work in a variety of ways, not all of which are understood.
-
- Inhalational anaesthetics include Nitrous Oxide, Halothane,
- Enflurane, Isoflurane, Desflurane and Servoflurane. They are
- breathed in via anaesthetic machines and produce a dense amnesia
- in sufficient concentrations.
-
- Intravenous agents include Thiopentone, Methohexitone, Ketamine,
- Propofol, Etomidate and Benzodiazepines.
-
- You will perhaps note that some of the above get write ups in
- this news group and alt.drugs, as in lower doses they produce
- altered levels of conscious function before inducing anaesthesia.
-
- One class of the above stands out in producing amnesia before
- it produces a full loss of consciousness: the Benzodiazepines.
-
- They work by increasing the effects of a neurotransmitter in the
- brain known as GABA (which is an inhibitory transmitter, ie., it
- tends to reduce the overall level of brain activity).
-
- Benzodiazepines include the original diazepam (Valium) and many
- newer varients, including lorazepam, oxazepam, nitrazepam,
- flunitrazepam, and midazolam.
-
- All tend to produce amnesia, but midazolam and lorazepam are noted
- to produce amnesia reliably with dosages much lower than that which
- will produce an anaesthetic state. A low dose may provide minimal
- sedation and the person will look and behave fairly normally, but
- will not remember much if anything.
-
- Xanax is from memory alprazolam, and may have some amnestic effect,
- in some or most people, in sufficient dosage. I suspect that Steve
- Dyer could say how common this is, but I would think that it would
- be less common than with midazolam or lorazepam (especially in terms
- of commonly used doses for each).
-
- >=====================================================================
- >= H A V E A D A Y :| =
- >=====================================================================
-
- Like the .sig.
-
- Michael
-
- --
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-
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