home *** CD-ROM | disk | FTP | other *** search
- $Unique_ID{BRK02159}
- $Pretitle{}
- $Title{Cushing's Disease}
- $Subject{Cushing Cushing's Disease neurosurgery pituitary gland sphenoid bone
- hormones thyroid ovaries blood pressure adrenal adrenocorticotropic
- cortisol rounded face skin neck abdomen metabolism sugar osteoporosis
- infection mental disturbances irradiation tumor}
- $Volume{}
- $Log{
- Location and Function of the Endocrine Glands*0002901.scf}
-
- Copyright (c) 1993 Tribune Media Services, Inc.
-
-
- Cushing's Disease
-
-
- ------------------------------------------------------------------------------
-
- QUESTION: Although I received a rather long and complete explanation of the
- Cushing's Illness from my own doctor, I think he went a bit faster than my
- mind could hold, and so I still don't know what it means. Yet I know it is
- serious, and hope you can explain where it comes from. Then maybe I can
- understand why I look the way I do.
-
- ------------------------------------------------------------------------------
-
- ANSWER: One of the medical geniuses of the last century was Dr. Harvey
- Cushing, of Cleveland Ohio, and a professor of surgery at Johns Hopkins and
- Harvard University. His work in neurosurgery was outstanding, and he provided
- medical science with a great deal of knowledge about the pituitary gland. The
- pituitary gland is a very small, but extremely important organ that sits under
- the center of the brain in a small protective pocket of bone in the sphenoid
- bone. It has two lobes, and each produces a number of hormones that act both
- directly and indirectly on other body functions. Thus it acts on the thyroid,
- the ovaries, helps control blood pressure, and most important for you,
- secretes a hormone that acts on the adrenal gland. Stick with me now, for
- here's where it gets a bit complicated. The hormone is known as
- adrenocorticotropic hormone (or ACTH). It stimulates the adrenal gland to
- secrete cortisol, a cortisone-like hormone that is essential to the body
- functions. When too much ACTH is produced, as in the case of a hormone
- producing tumor of the pituitary, too much cortisol is released into the body,
- producing the condition known as Cushing's Disease. This results in a rounded
- "moon" like face, the development of prominent fat pads at the back of the
- neck (named "buffalo humps"), thin pale skin, and long purple lines (striae)
- across the abdomen. Problems with the metabolism of sugar, osteoporosis,
- reduced resistance to infection and even mental disturbances are common. The
- solution lies in attacking the tumor, either by removing it surgically or
- using high voltage irradiation to kill the cells. The surgery is demanding
- and is only performed in specialized centers. Now with this new explanation
- (which I hope helps you to understand), return to your doctor for additional
- explanations. This is indeed a complicated situation, so take all the time
- you need to get answers you understand.
-
- ----------------
-
- The material contained here is "FOR INFORMATION ONLY" and should not replace
- the counsel and advice of your personal physician. Promptly consulting your
- doctor is the best path to a quick and successful resolution of any medical
- problem.
-