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1994-08-27
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Document 0791
DOCN M9480791
TI Adult T cell leukaemia-lymphoma.
DT 9410
AU Yamaguchi K; Takatsuki K; Blood Transfusion Service, Kumamoto University
Medical School,; Japan.
SO Baillieres Clin Haematol. 1993 Dec;6(4):899-915. Unique Identifier :
AIDSLINE MED/94312759
AB Adult T cell leukaemia-lymphoma (ATL) was first discovered and reported
in Japan, where it has a high incidence in the south-west region. The
first human retrovirus HTLV-I (human T-cell lymphotropic virus type I)
is considered to be related to its aetiology. In ATL endemic areas,
HTLV-I carriers form a fairly high percentage of the population, even
among healthy individuals. ATL shows diverse clinical features. It can
be divided into four subtypes: acute, chronic, smouldering and lymphoma
type. ATL cells originate from the CD4-positive subset of peripheral T
cells; they show a characteristic notch in the nucleus and a tendency to
lobulation. ATL resists chemotherapy, and patients with acute and
lymphoma types have a fairly poor prognosis. A definite diagnosis of ATL
is made by documenting the presence of HTLV-I proviral DNA in the DNA of
tumour cells. HTLV-I infection is caused by transmission of live
lymphocytes via three routes (from mother to child, from males to
females, and by transfusion). Familial occurrence of ATL is frequently
seen. HTLV-I infection is seen in other countries, but its incidence is
highest in Japan. Infection with HTLV-I is a direct cause of ATL.
Furthermore, infection with this virus can indirectly cause many other
diseases via the induction of immunodeficiency, such as chronic lung
disease, opportunistic lung infection, cancer of other organs,
monoclonal gammopathy, chronic renal failure, strongyloidiasis,
non-specific dermatomycosis, HTLV-I-associated lymphadenitis, HTLV-I
uveitis and HTLV-I-associated myelopathy-tropical spastic paraparesis
(HAM/TSP).
DE Adult Aged Aged, 80 and over Antineoplastic Agents,
Combined/THERAPEUTIC USE Caribbean Region/ETHNOLOGY/EPIDEMIOLOGY
Female Human Hypercalcemia/ETIOLOGY HTLV-I/ISOLATION &
PURIF/PATHOGENICITY Incidence Japan/EPIDEMIOLOGY *Leukemia-Lymphoma,
T-Cell, Acute, HTLV-I-Associated/
CLASSIFICATION/COMPLICATIONS/DIAGNOSIS/DRUG THERAPY/EPIDEMIOLOGY/
MICROBIOLOGY/PATHOLOGY/TRANSMISSION Lung Diseases/ETIOLOGY Male
Middle Age Neoplasms, Second Primary/EPIDEMIOLOGY
Pentostatin/THERAPEUTIC USE Tumor Stem Cells/PATHOLOGY
Uveitis/ETIOLOGY JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).