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1994-08-27
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Document 0790
DOCN M9480790
TI Methylprednisolone bolus: a novel therapy for severe atopic dermatitis.
DT 9410
AU Galli E; Chini L; Moschese V; Paone F; Menichelli A; Fraioli G; Rossi P;
Institute of Paediatrics, University of Rome Tor Vergata, Italy.
SO Acta Paediatr. 1994 Mar;83(3):315-7. Unique Identifier : AIDSLINE
MED/94312804
AB Seven children suffering from severe atopic dermatitis, unresponsive to
standard therapy, received an iv bolus dose of methylprednisolone (20
mg/kg/day) for three days. Immunological parameters were evaluated
before and after treatment. At the end of bolus therapy both skin
lesions and itching improved for several months in five of seven
patients. No side effects were observed, but a significant and transient
lymphopenic response occurred, with lower CD4+ than CD8+ lymphocyte
counts. Our data suggest that this therapy may be a novel and safe
therapeutic approach in severe atopic dermatitis.
DE Adolescence Child Child, Preschool CD4-CD8 Ratio Dermatitis,
Atopic/*DRUG THERAPY/IMMUNOLOGY Female Human Immunoglobulins/ANALYSIS
Injections, Intravenous Male Methylprednisolone/*ADMINISTRATION &
DOSAGE Support, Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).