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1994-08-27
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Document 0788
DOCN M9480788
TI Human immunodeficiency virus type 1 and type 2 seroprevalence in cornea
donors.
DT 9410
AU Geier SA; Klauss V; Gurtler L; University Eye Hospital Munich, Germany.
SO Ger J Ophthalmol. 1994 May;3(3):182-5. Unique Identifier : AIDSLINE
MED/94312983
AB Routine screening of cornea donors for human immunodeficiency virus type
1 (HIV-1) has been established and has reduced the risk of HIV-1
transmission to a minimum. Screening for HIV-2 is less common. We
evaluated 100 cornea donors for HIV-2 and 166 cornea donors for HIV-1
according to our routine screening procedure. Enzyme-linked
immunosorbent assays (ELISAs) with high sensitivity were used to detect
antibodies in donor blood. HIV-2 seroconversion was not found in any of
the 100 cases tested, whereas HIV-1 seroconversion was detected in 4 of
166 cases; consecutive Western-blot analysis showed only 1 positive
result. Thus, 1 of 166 cases (0.6%) had to be considered infected with
HIV-1. Our findings of HIV-1 seroprevalence are comparable with those
obtained in studies carried out in Europe and the United States. Data
are lacking for comparison with our results concerning HIV-2
seroprevalence. Because of the epidemiologic situation of HIV-2 in
Europe, different seroprevalence rates would be expected. Routine
screening of potential cornea donors for HIV-2 in Germany may be
necessary only if the seroprevalence rises in the population.
DE Adolescence Adult Aged *Cornea/MICROBIOLOGY Corneal
Diseases/EPIDEMIOLOGY/MICROBIOLOGY Eye Infections, Viral/EPIDEMIOLOGY
Female Germany/EPIDEMIOLOGY Human HIV Infections/*EPIDEMIOLOGY HIV
Seropositivity/EPIDEMIOLOGY *HIV Seroprevalence *HIV-1 *HIV-2 Male
Middle Age Support, Non-U.S. Gov't *Tissue Donors JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).