Document 0788
 DOCN  M9480788
 TI    Human immunodeficiency virus type 1 and type 2 seroprevalence in cornea
       donors.
 DT    9410
 AU    Geier SA; Klauss V; Gurtler L; University Eye Hospital Munich, Germany.
 SO    Ger J Ophthalmol. 1994 May;3(3):182-5. Unique Identifier : AIDSLINE
       MED/94312983
 AB    Routine screening of cornea donors for human immunodeficiency virus type
       1 (HIV-1) has been established and has reduced the risk of HIV-1
       transmission to a minimum. Screening for HIV-2 is less common. We
       evaluated 100 cornea donors for HIV-2 and 166 cornea donors for HIV-1
       according to our routine screening procedure. Enzyme-linked
       immunosorbent assays (ELISAs) with high sensitivity were used to detect
       antibodies in donor blood. HIV-2 seroconversion was not found in any of
       the 100 cases tested, whereas HIV-1 seroconversion was detected in 4 of
       166 cases; consecutive Western-blot analysis showed only 1 positive
       result. Thus, 1 of 166 cases (0.6%) had to be considered infected with
       HIV-1. Our findings of HIV-1 seroprevalence are comparable with those
       obtained in studies carried out in Europe and the United States. Data
       are lacking for comparison with our results concerning HIV-2
       seroprevalence. Because of the epidemiologic situation of HIV-2 in
       Europe, different seroprevalence rates would be expected. Routine
       screening of potential cornea donors for HIV-2 in Germany may be
       necessary only if the seroprevalence rises in the population.
 DE    Adolescence  Adult  Aged  *Cornea/MICROBIOLOGY  Corneal
       Diseases/EPIDEMIOLOGY/MICROBIOLOGY  Eye Infections, Viral/EPIDEMIOLOGY
       Female  Germany/EPIDEMIOLOGY  Human  HIV Infections/*EPIDEMIOLOGY  HIV
       Seropositivity/EPIDEMIOLOGY  *HIV Seroprevalence  *HIV-1  *HIV-2  Male
       Middle Age  Support, Non-U.S. Gov't  *Tissue Donors  JOURNAL ARTICLE

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