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1994-08-27
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Document 0755
DOCN M9480755
TI Polyclonal B-cell activation in cats infected with feline
immunodeficiency virus.
DT 9410
AU Flynn JN; Cannon CA; Lawrence CE; Jarrett O; MRC Retrovirus Laboratory,
Department of Veterinary Pathology,; University of Glasgow, U.K.
SO Immunology. 1994 Apr;81(4):626-30. Unique Identifier : AIDSLINE
MED/94314349
AB The specificity of the antibody response following natural or
experimental infection of domestic cats with feline immunodeficiency
virus (FIV) was examined. The antibody response to a range of non-viral
antigens, including trinitrophenol (TNP), ovalbumin, beta-galactosidase,
deoxyribonucleic acid (DNA) and keyhole limpet haemocyanin (KLH), was
measured in 220 cats naturally infected with FIV. Infected cats had
higher antibody levels to these antigens, in particular TNP, KLH and
beta-galactosidase, than non-infected control cats. Competition binding
studies demonstrated that this response was not due to the presence of
cross-reacting epitopes on recombinant FIV p17 or p24 antigens,
suggesting that the B-cell activation associated with infection was
polyclonal rather than entirely virus specific. Studies on cats
experimentally infected with FIV revealed a similar pattern, with
infected cats developing an antibody response to heterologous non-viral
antigens at 6-8 weeks post-infection. There were two discernible peaks
of antibody activity, the first occurring 10-20 weeks post-infection and
the second peak 40-60 weeks post-infection. The antibody response to
KLH, DNA and beta-galactosidase remained elevated throughout the 90-week
study period, whereas the antibody levels to the other antigens declined
to levels approaching those observed in normal cats.
DE beta-Galactosidase/IMMUNOLOGY Animal Antibodies, Heterophile/BLOOD
Antibodies, Viral/BLOOD Antigenic Determinants/IMMUNOLOGY
B-Lymphocytes/*IMMUNOLOGY Binding, Competitive Cat
Diseases/*IMMUNOLOGY Cats DNA/IMMUNOLOGY Hemocyanin/IMMUNOLOGY
Immunodeficiency Virus, Feline/*IMMUNOLOGY Lentivirus
Infections/*IMMUNOLOGY Lymphocyte Transformation/*IMMUNOLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).