Document 0755
 DOCN  M9480755
 TI    Polyclonal B-cell activation in cats infected with feline
       immunodeficiency virus.
 DT    9410
 AU    Flynn JN; Cannon CA; Lawrence CE; Jarrett O; MRC Retrovirus Laboratory,
       Department of Veterinary Pathology,; University of Glasgow, U.K.
 SO    Immunology. 1994 Apr;81(4):626-30. Unique Identifier : AIDSLINE
       MED/94314349
 AB    The specificity of the antibody response following natural or
       experimental infection of domestic cats with feline immunodeficiency
       virus (FIV) was examined. The antibody response to a range of non-viral
       antigens, including trinitrophenol (TNP), ovalbumin, beta-galactosidase,
       deoxyribonucleic acid (DNA) and keyhole limpet haemocyanin (KLH), was
       measured in 220 cats naturally infected with FIV. Infected cats had
       higher antibody levels to these antigens, in particular TNP, KLH and
       beta-galactosidase, than non-infected control cats. Competition binding
       studies demonstrated that this response was not due to the presence of
       cross-reacting epitopes on recombinant FIV p17 or p24 antigens,
       suggesting that the B-cell activation associated with infection was
       polyclonal rather than entirely virus specific. Studies on cats
       experimentally infected with FIV revealed a similar pattern, with
       infected cats developing an antibody response to heterologous non-viral
       antigens at 6-8 weeks post-infection. There were two discernible peaks
       of antibody activity, the first occurring 10-20 weeks post-infection and
       the second peak 40-60 weeks post-infection. The antibody response to
       KLH, DNA and beta-galactosidase remained elevated throughout the 90-week
       study period, whereas the antibody levels to the other antigens declined
       to levels approaching those observed in normal cats.
 DE    beta-Galactosidase/IMMUNOLOGY  Animal  Antibodies, Heterophile/BLOOD
       Antibodies, Viral/BLOOD  Antigenic Determinants/IMMUNOLOGY
       B-Lymphocytes/*IMMUNOLOGY  Binding, Competitive  Cat
       Diseases/*IMMUNOLOGY  Cats  DNA/IMMUNOLOGY  Hemocyanin/IMMUNOLOGY
       Immunodeficiency Virus, Feline/*IMMUNOLOGY  Lentivirus
       Infections/*IMMUNOLOGY  Lymphocyte Transformation/*IMMUNOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).