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1994-08-27
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Document 0744
DOCN M9480744
TI Intermediates in the oxidation of a dihydropyridine derivative of AZT
related to AIDS dementia, studied by nanosecond laser photolysis.
DT 9410
AU Lindqvist L; Czochralska B; Kawczynski W; Laboratoire de Photophysique
Moleculaire, Universite de; Paris-Sud, Orsay, France.
SO J Photochem Photobiol B. 1994 May;23(2-3):207-11. Unique Identifier :
AIDSLINE MED/94315484
AB Radicals of the AZT derivative
5'-(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3'-azido-2',3'-dide- o
xythymidine) were obtained on exposure of this compound in alkaline
aqueous solution to pulsed laser emission of lambda = 355 nm and
pulsewidth 2 ns FWHM. The radical formation was shown to be due to
photoelectron ejection from the pyridine group following two-step
excitation of the compound. The radicals were found to deprotonate
rapidly. Electrochemical analysis showed that the photoionization does
not affect the azido group.
DE AIDS Dementia Complex/*DRUG THERAPY
Dihydropyridines/*CHEMISTRY/METABOLISM/THERAPEUTIC USE Human Lasers
Photolysis Support, Non-U.S. Gov't Time Factors Zidovudine/*ANALOGS &
DERIVATIVES/CHEMISTRY/METABOLISM/ THERAPEUTIC USE JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).