Document 0744
 DOCN  M9480744
 TI    Intermediates in the oxidation of a dihydropyridine derivative of AZT
       related to AIDS dementia, studied by nanosecond laser photolysis.
 DT    9410
 AU    Lindqvist L; Czochralska B; Kawczynski W; Laboratoire de Photophysique
       Moleculaire, Universite de; Paris-Sud, Orsay, France.
 SO    J Photochem Photobiol B. 1994 May;23(2-3):207-11. Unique Identifier :
       AIDSLINE MED/94315484
 AB    Radicals of the AZT derivative
       5'-(1,4-dihydro-1-methyl-3-pyridinylcarbonyl)-3'-azido-2',3'-dide- o
       xythymidine) were obtained on exposure of this compound in alkaline
       aqueous solution to pulsed laser emission of lambda = 355 nm and
       pulsewidth 2 ns FWHM. The radical formation was shown to be due to
       photoelectron ejection from the pyridine group following two-step
       excitation of the compound. The radicals were found to deprotonate
       rapidly. Electrochemical analysis showed that the photoionization does
       not affect the azido group.
 DE    AIDS Dementia Complex/*DRUG THERAPY
       Dihydropyridines/*CHEMISTRY/METABOLISM/THERAPEUTIC USE  Human  Lasers
       Photolysis  Support, Non-U.S. Gov't  Time Factors  Zidovudine/*ANALOGS &
       DERIVATIVES/CHEMISTRY/METABOLISM/  THERAPEUTIC USE  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).