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1994-08-27
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Document 0685
DOCN M9480685
TI [Attrition, dentin apposition and protein synthesis in the pulp and
desmodont of young and old rats]
DT 9410
AU Schroeder HE; Munzel-Pedrazzoli S; Abteilung fur Orale Strukturbiologie,
Universitat Zurich.
SO Schweiz Monatsschr Zahnmed. 1994;104(6):731-9. Unique Identifier :
AIDSLINE MED/94316984
AB Occlusal attrition and responsive adaptations in the pulp-dentinal unit
are still problematic. In this study, up to 2 years-old rats were used
to measure the amount of occlusal attrition, of dentin apposition and of
the incorporation of 3H-proline into the pulpal and periodontal ligament
tissues. Two to four SIV-rats each, 45, 365 and 730 days of age, were
once injected with 3H-proline 2 hours or 5 days prior to exitus. After
cardiac perfusion, the molar blocks of both jaws were decalcified in
EDTA and divided into bucco-oral and mesio-distal slices. The latter
were embedded in Epon. Semithin sections served to measure the amount of
attrition and of tertiary dentin apposition, as well as for
autoradiographic labelling and determination of the rate of dentin
apposition and proline incorporation in pulpal and periodontal ligament
tissues. The results show that (1) the molar cusps lost up to 40% of
their initial height during the two years of life, (2) occlusal dentin
apposition in the intercuspal region led to an increase in dentinal
thickness by 50 to 70%, while in the pulp horn region dentinal
apposition occurred early in life and later did not keep phase with
attrition, and (3) protein synthesis in pulp and periodontal ligament
essentially did not change within the two years of life. These findings
are related to that of other authors and discussed in connection with
dentinal innervation.
DE Aging/*METABOLISM Animal Autoradiography Comparative Study Dental
Pulp Cavity/*METABOLISM Dentinogenesis/*PHYSIOLOGY English Abstract
Molar/METABOLISM/PATHOLOGY Periodontal Ligament/*METABOLISM
Proline/METABOLISM Proteins/*BIOSYNTHESIS Rats Support, Non-U.S.
Gov't Tooth Abrasion/METABOLISM/*PATHOLOGY Tritium JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).