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1994-08-27
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Document 0659
DOCN M9480659
TI Anti-neutrophil antibodies of the immunoglobulin M class in autoimmune
neutropenia.
DT 9410
AU Hartman KR; Department of Hematology, Walter Reed Army Institute of
Research,; Washington, DC 20307-5100.
SO Am J Med Sci. 1994 Aug;308(2):102-5. Unique Identifier : AIDSLINE
MED/94317680
AB Anti-neutrophil antibodies of the immunoglobulin G (IgG) class have been
implicated in the pathogenesis of autoimmune neutropenia, but few
reports have described immunoglobulin M (IgM) anti-neutrophil
antibodies. To investigate the prevalence of IgM anti-neutrophil
antibodies, sera from 130 patients with possible autoimmune neutropenia
were studied for IgG and IgM anti-neutrophil antibodies using an
immunofluorescence flow cytometric assay. Twenty-five patients (19%) had
IgG anti-neutrophil antibodies exclusively, 21 patients (16%) had both
IgG and IgM anti-neutrophil antibodies, and 11 patients (8%) had IgM
anti-neutrophil antibodies exclusively. Immunoglobulin M anti-neutrophil
antibodies were found in adults and children with isolated chronic
neutropenia and in patients with Felty's syndrome, systemic lupus
erythematosus, immune thrombocytopenic purpura, and human
immunodeficiency virus. Patients with neutropenia with only IgM
anti-neutrophil antibodies comprised almost 20% of antibody-positive
patients in this study.
DE Adult Aged Aged, 80 and over Autoantibodies/*BLOOD Autoimmune
Diseases/*IMMUNOLOGY Child, Preschool Female Flow Cytometry Human
IgG/BLOOD IgM/*BLOOD Immunoblotting Infant Male Middle Age
Neutropenia/*IMMUNOLOGY Neutrophils/*IMMUNOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).