Document 0659
 DOCN  M9480659
 TI    Anti-neutrophil antibodies of the immunoglobulin M class in autoimmune
       neutropenia.
 DT    9410
 AU    Hartman KR; Department of Hematology, Walter Reed Army Institute of
       Research,; Washington, DC 20307-5100.
 SO    Am J Med Sci. 1994 Aug;308(2):102-5. Unique Identifier : AIDSLINE
       MED/94317680
 AB    Anti-neutrophil antibodies of the immunoglobulin G (IgG) class have been
       implicated in the pathogenesis of autoimmune neutropenia, but few
       reports have described immunoglobulin M (IgM) anti-neutrophil
       antibodies. To investigate the prevalence of IgM anti-neutrophil
       antibodies, sera from 130 patients with possible autoimmune neutropenia
       were studied for IgG and IgM anti-neutrophil antibodies using an
       immunofluorescence flow cytometric assay. Twenty-five patients (19%) had
       IgG anti-neutrophil antibodies exclusively, 21 patients (16%) had both
       IgG and IgM anti-neutrophil antibodies, and 11 patients (8%) had IgM
       anti-neutrophil antibodies exclusively. Immunoglobulin M anti-neutrophil
       antibodies were found in adults and children with isolated chronic
       neutropenia and in patients with Felty's syndrome, systemic lupus
       erythematosus, immune thrombocytopenic purpura, and human
       immunodeficiency virus. Patients with neutropenia with only IgM
       anti-neutrophil antibodies comprised almost 20% of antibody-positive
       patients in this study.
 DE    Adult  Aged  Aged, 80 and over  Autoantibodies/*BLOOD  Autoimmune
       Diseases/*IMMUNOLOGY  Child, Preschool  Female  Flow Cytometry  Human
       IgG/BLOOD  IgM/*BLOOD  Immunoblotting  Infant  Male  Middle Age
       Neutropenia/*IMMUNOLOGY  Neutrophils/*IMMUNOLOGY  JOURNAL ARTICLE

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