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M94A0089.TXT
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1994-10-01
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Document 0089
DOCN M94A0089
TI Clinical significance of positive direct antiglobulin test in patients
with HIV infection.
DT 9412
AU De Angelis V; Biasinutto C; Pradella P; Vaccher E; Spina M; Tirelli U;
Servizio Immunotrasfusionale e Analisi Cliniche, I.R.C.C.S.; Centro di
Riferimento Oncologico, Aviano, Italy.
SO Infection. 1994 Mar-Apr;22(2):92-5. Unique Identifier : AIDSLINE
MED/94350513
AB A direct antiglobulin test (DAT) was performed in 70 patients with
anti-HIV antibodies (group A: seropositive patients without or with
minimal disease and group B: AIDS patients with or without
malignancies). A positive DAT was found in 24 of 70 patients (34%,
significantly higher compared to 0.1% in healthy controls) and a higher
prevalence of positive DAT was observed in group B than in group A
patients (55% versus 21% p < 0.01). When comparing DAT-positive and
negative patients within the same clinical group, no significant
difference is seen in haemoglobin levels. There is no difference in
serum bilirubin, haptoglobin or reticulocyte count between DAT-positive
and negative patients altogether or in the same clinical group. AZT
therapy seems to exert no significant influence on the onset of a
positive DAT. The results confirm a high prevalence of positive DAT in
patients with HIV antibodies, mainly in worse clinical conditions, and
suggest that a positive DAT might be a prognostic factor in the clinical
course of the disease.
DE Adult Anemia, Hemolytic/*BLOOD/EPIDEMIOLOGY/*ETIOLOGY Bilirubin/BLOOD
Case-Control Studies *Coombs' Test CD4-CD8 Ratio Female
Haptoglobins/ANALYSIS Hematocrit Hemoglobins/ANALYSIS Human HIV
Antibodies/BLOOD HIV Infections/CLASSIFICATION/*COMPLICATIONS Male
Middle Age Prevalence Prognosis Reticulocyte Count Risk Factors
Severity of Illness Index JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).