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M94A0084.TXT
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1994-10-01
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Document 0084
DOCN M94A0084
TI The mniopetals, new inhibitors of reverse transcriptases from a
Mniopetalum species (Basidiomycetes). I. Producing organism,
fermentation, isolation and biological activities.
DT 9412
AU Kuschel A; Anke T; Velten R; Klostermeyer D; Steglich W; Konig B; LB
Biotechnology, The University, Kaiserslautern, FRG.
SO J Antibiot (Tokyo). 1994 Jul;47(7):733-9. Unique Identifier : AIDSLINE
MED/94350715
AB Six novel enzyme inhibitors of RNA-directed DNA-polymerases of human
immunodeficiency-, avian myeloblastosis and murine leukemia viruses were
isolated from fermentations of a canadian Mniopetalum species. They were
named mniopetals A, B, C, D, E and F. Their structures were elucidated
by spectroscopic methods. The compounds, in addition to their inhibitory
activities on reverse transcriptases, exhibit antimicrobial and
cytotoxic properties.
DE Antibiotics, Antifungal/*BIOSYNTHESIS/ISOLATION & PURIF/ *PHARMACOLOGY
Antiviral Agents/*CHEMICAL SYNTHESIS/ISOLATION & PURIF/ *PHARMACOLOGY
Basidiomycetes/*CHEMISTRY/*METABOLISM Fermentation HIV-1/ENZYMOLOGY
Moloney Leukemia Virus/ENZYMOLOGY Myeloblastosis Virus,
Avian/ENZYMOLOGY Reverse Transcriptase/*ANTAGONISTS & INHIB Support,
Non-U.S. Gov't Viral Proteins/ANTAGONISTS & INHIB JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).