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M94A0019.TXT
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1994-10-01
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Document 0019
DOCN M94A0019
TI Effect of glycyrrhizin in children with liver dysfunction associated
with cytomegalovirus infection.
DT 9412
AU Numazaki K; Umetsu M; Chiba S; Department of Pediatrics, School of
Medicine, Sapporo Medical; University, Japan.
SO Tohoku J Exp Med. 1994 Feb;172(2):147-53. Unique Identifier : AIDSLINE
MED/94353395
AB Glycyrrhizin (GL) has an inhibitory effect on several viruses including
human immunodeficiency virus type 1 (HIV-1) and varicella-zoster virus
(VZV). In addition, some therapeutic and prophylactic effects on chronic
active viral hepatitis have been claimed for GL. In this study, 0.2% GL
dissolved in saline (2 mg/ml GL), supplemented with 2% glycine and 0.1%
cysteine (Stronger Neo-Minophagen C, SNMC) was administered
intravenously in a dose of 50 ml/day for a period of more than one week
to three infants with cytomegalovirus (CMV) infection who exhibited
abnormal liver function or hepatomegaly. Liver function had become
normal at the end of the course of SNMC. These findings suggest that GL
might have therapeutic effects on liver dysfunction associated with CMV
infections.
DE Antibodies, Viral/ANALYSIS Antiviral Agents/ADMINISTRATION &
DOSAGE/*THERAPEUTIC USE Case Report
Cytomegalovirus/IMMUNOLOGY/ISOLATION & PURIF Cytomegalovirus
Infections/COMPLICATIONS/*DRUG THERAPY Female Glycyrrhetinic
Acid/*ANALOGS & DERIVATIVES/ADMINISTRATION & DOSAGE/THERAPEUTIC USE
Human IgG/ANALYSIS IgM/ANALYSIS Infant Infusions, Intravenous Liver
Diseases/*DRUG THERAPY/MICROBIOLOGY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).