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M94A0016.TXT
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1994-10-01
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Document 0016
DOCN M94A0016
TI Sequence variation in the gp135 gene of Maedi visna virus strain EV1.
DT 9412
AU Carey N; Dalziel RG; Department of Veterinary Pathology, University of
Edinburgh,; Summerhall.
SO Virus Genes. 1994 Mar;8(2):115-23. Unique Identifier : AIDSLINE
MED/94353637
AB We have used the PCR and HIRT DNA obtained from MVV-infected tissue
culture cells as a template to generate a number of independently
derived clones representing overlapping fragments of the gp135 region
(env) of Maedi visna virus (MVV) strain EV1. Sequencing these clones
revealed that homology between selected regions of gp135 ranged from
93.2% to 99.8%. Four hypervariable regions and one large highly
conserved region have been identified. These data provide information on
the variability of EV1 env, which extends and complements the data
previously available on env variability between geographically distinct
isolates of MVV.
DE Amino Acid Sequence Base Sequence Cloning, Molecular Genes,
env/*GENETICS Molecular Sequence Data Sequence Analysis, DNA Sequence
Homology, Amino Acid Variation (Genetics)/*GENETICS Viral Envelope
Proteins/*GENETICS Visna-Maedi Virus/*GENETICS JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).