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M94A0012.TXT
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1994-10-01
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Document 0012
DOCN M94A0012
TI [The specific activity and immunological safety of the intranasal method
of revaccination with a live measles vaccine made from the Leningrad-16
strain]
DT 9412
AU Iuminova NV; Krasnova VP; Liashenko VA; Vedunova SL
SO Vopr Virusol. 1993 May-Jun;38(3):111-3. Unique Identifier : AIDSLINE
MED/94353760
AB The search for alternative routes for administration of live measles
vaccine is associated both with the threat of infection with human
immunodeficiency virus, hepatitis B virus, and with the development of a
more physiological, natural and less traumatic mode of vaccine
administration. The influence of the intranasal administration on the
general condition of the immune system, its immunomodulating effect (the
emergence of inducer suppressors, cell response to the inactivated
virus), was studied as well as the level and intensity of secretory and
general humoral immunity. The studies confirmed the immunological
effectiveness and safety of the intranasal administration of a live
measles vaccine and suggested its advantages for revaccination against
measles.
DE Administration, Intranasal Adolescence Adult Antibodies, Viral/BLOOD
Antibody Specificity Antigenic Determinants/IMMUNOLOGY Antigens,
Viral/IMMUNOLOGY Comparative Study Dose-Response Relationship,
Immunologic English Abstract Human IgA/BLOOD IgG/BLOOD
Immunization, Secondary/ADVERSE EFFECTS/*METHODS Measles
Vaccine/ADMINISTRATION & DOSAGE/ADVERSE EFFECTS/ *IMMUNOLOGY Measles
Virus/IMMUNOLOGY Safety Time Factors JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).