Hall of Fame/HallofFameCDROM.cdr/open/medlit31.lzh/VALIUM.TXT

Text File | 1986-04-28 | 20KB | 456 lines

       1
AN 83101075.  8300.
AU Yim-A-P.
IN University Department of Pathology, Cambridge.
TI Some flow-cytofluorimetric studies of the nuclear ploidy of mouse
   hepatocytes: iii.  further observations on early changes in nuclear
   ploidy of mouse hepatocytes following various experimental
   procedures.
SO Br-J-Exp-Pathol. 1982 Aug. 63(4). P 458-61.
LG EN.
AB Distribution of nuclear ploidy in female mouse hepatocytes was
   measured cytofluorimetrically using ethidium-bromide-stained
   hepatocyte nuclei liberated by in situ collagenase perfusion of the
   liver via the portal vein.  After i.v.  administration of lead
   acetate or an i.p.  general anaesthetic *(Valium* and Hypnorm), rapid
   shifts of 8N and 4N nuclei to lower ploidy levels were recorded.  It
   was possible to block the ploidy changes with i.p.  colchicine,
   although no blocked metaphases were observed histologically.  These
   observations were consistent with an earlier report on changes in
   nuclear ploidy induced by carbon tetrachloride (Steele et al.,
   1981b).  It is speculated that these changes in ploidy may represent
   an early response of the hepatocytes to stimulation--an aspect of
   liver behaviour of which we were not previously aware.  Author.
MJ LIVER: cy.  PLOIDIES.
MN ANIMAL.  BUTYROPHENONES: pd.  CELL-DIVISION: de.  COLCHICINE: pd.
   CYTOGENETICS.  DIAZEPAM: pd.  DRUG-COMBINATIONS: pd.  FEMALE.
   *FENTANYL:* pd.  FLOW-CYTOMETRY.  LAPAROTOMY.  LEAD: pd.  MICE.
   MITOSIS: de.  PLOIDIES: de.
RN 301-04-2 -- lead-acetate.
   437-38-7 -- *Fentanyl.*
   439-14-5 -- Diazepam.
   52869-98-4 -- Hypnorm.
   64-86-8 -- Colchicine.
   7439-92-1 -- Lead.
YR 82.
IS 0007-1021.
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      11
AN 70190346.  7000.
AU Mulder-J-A.
TI [Valium-fentanyl, a black swan?].
TT Valium-fentanyl, een witte raaf?.
SO Ned-Tijdschr-Geneeskd. 1970 May 23. 114(21). P 867-9.
LG DU.
MJ DIAZEPAM.  *FENTANYL.*  NEUROLEPTANALGESIA.
MN BENPERIDOL: ae.  DRUG-SYNERGISM.  ENGLISH-ABSTRACT.  HUMAN.  MUSCLES:
   de.
YR 70.
IS 0028-2162.
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       1
AN 83101075.  8300.
AU Yim-A-P.
IN University Department of Pathology, Cambridge.
TI Some flow-cytofluorimetric studies of the nuclear ploidy of mouse
   hepatocytes: iii.  further observations on early changes in nuclear
   ploidy of mouse hepatocytes following various experimental
   procedures.
SO Br-J-Exp-Pathol. 1982 Aug. 63(4). P 458-61.
LG EN.
AB Distribution of nuclear ploidy in female mouse hepatocytes was
   measured cytofluorimetrically using ethidium-bromide-stained
   hepatocyte nuclei liberated by in situ collagenase perfusion of the
   liver via the portal vein.  After i.v.  administration of lead
   acetate or an i.p.  general anaesthetic *(Valium* and Hypnorm), rapid
   shifts of 8N and 4N nuclei to lower ploidy levels were recorded.  It
   was possible to block the ploidy changes with i.p.  colchicine,
   although no blocked metaphases were observed histologically.  These
   observations were consistent with an earlier report on changes in
   nuclear ploidy induced by carbon tetrachloride (Steele et al.,
   1981b).  It is speculated that these changes in ploidy may represent
   an early response of the hepatocytes to stimulation--an aspect of
   liver behaviour of which we were not previously aware.  Author.
MJ LIVER: cy.  PLOIDIES.
MN ANIMAL.  BUTYROPHENONES: pd.  CELL-DIVISION: de.  COLCHICINE: pd.
   CYTOGENETICS.  DIAZEPAM: pd.  DRUG-COMBINATIONS: pd.  FEMALE.
   *FENTANYL:* pd.  FLOW-CYTOMETRY.  LAPAROTOMY.  LEAD: pd.  MICE.
   MITOSIS: de.  PLOIDIES: de.
RN 301-04-2 -- lead-acetate.
   437-38-7 -- *Fentanyl.*
   439-14-5 -- Diazepam.
   52869-98-4 -- Hypnorm.
   64-86-8 -- Colchicine.
   7439-92-1 -- Lead.
YR 82.
IS 0007-1021.

       2
AN 82282013.  8200.
AU Bahar-M.  McAteer-E.  Dundee-J-W.  Briggs-L-P.
IN Department of Anaesthetics, the Queens's University of Belfast,
   Northern Ireland.
TI Aspirin in the prevention of painful intravenous injection of
   disoprofol (ICI35,868) and diazepam *(Valium).*
SO Anaesthesia. 1982 Aug. 37(8). P 847-8.
LG EN.
MJ ANESTHETICS: ae.  ASPIRIN: tu.  DIAZEPAM: ae.  PAIN: pc.  PHENOLS:
   ae.
MN ADOLESCENCE.  ADULT.  ANESTHESIA-INTRAVENOUS: ae.  ASPIRIN: ad.
   COMPARATIVE-STUDY.  FEMALE.  *FENTANYL:* tu.  HUMAN.
   INJECTIONS-INTRAVENOUS.  MIDDLE-AGE.
RN 2078-54-8 -- disoprofol.
   437-38-7 -- *Fentanyl.*
   439-14-5 -- Diazepam.
   50-78-2 -- Aspirin.
YR 82.
IS 0003-2409.

       3
AN 80239912.  8000.
AU Huse-K.  Schaffer-R.  Fistas-G.
IN Institut fur Anasthesiologie der Universitat, Dusseldorf.
TI [Clinical experiences with diazepam *(Valium)* - *fentanyl* combination
   anesthesia in neurosurgery.  A study of circulation and oxygen
   consumption].
TT Klinische Erfahrungen mit der
   Diazepam-(Valium)-Fentanyl-Kombinationsnarkose in der Neurochirurgie.
   Untersuchungen des Kreislaufs und des Sauerstoffverbrauchs.
SO Anasth-Intensivther-Notfallmed. 1980 Apr. 15(2). P 135-43.
LG GE.
AB This clinical study was performed on 13 neurosurgical patients.  The
   mean age was 56 years (range 45-70 years).  After induction of
   anesthesia the heart rate diminished by 21.4%, the mean pressure by
   12.2% in the same time decreased the cardiac output by 19.3%, the
   calculated total peripheral resistance increased by 13%.  The oxygen
   uptake decreased by 16%.  The advantages and contraindications of
   this technique in neuroanesthesia are discussed.  Author.
MJ DIAZEPAM: ad.  *FENTANYL:* ad.  HEMODYNAMICS: de.  NERVOUS-SYSTEM: su.
   OXYGEN-CONSUMPTION: de.
MN AGED.  BLOOD-PRESSURE: de.  CARBON-DIOXIDE: bl.  CARDIAC-OUTPUT: de.
   DRUG-THERAPY-COMBINATION.  ENGLISH-ABSTRACT.  FEMALE.  HEART-RATE:
   de.  HUMAN.  MALE.  MIDDLE-AGE.  VASCULAR-RESISTANCE: de.
RN 437-38-7 -- *Fentanyl.*
   439-14-5 -- Diazepam.
YR 80.
IS 0174-1837.

       4
AN 80010584.  8000.
AU Giger-M.  Sonnenberg-A.  Weber-K-B.  Mattle-W.  Stuby-K.  Dolder-R.
   Blum-A-L.
IN Medizinische Klinik, Stadtspital Triemli, Zurich, Schweiz.
TI [Premedication of esophago-gastro-duodenoscopy with a
   neuroleptanalgesic drug and a tranquillizer--a controlled clinical
   study (author's transl)].
TT Neuroleptanalgesie und Tranquilizer als Pramedikation bei der
   Osophago-Gastro-Duodenoskopie--Eine kontrollierte klinische Studie.
SO Leber-Magen-Darm. 1979 Jun. 9(3). P 128-30.
LG GE.
AB In a controlled double-blind randomized study Thalamonal and *Valium*
   were compared in 498 esophago-gastro-duodenoscopies.  Both drugs
   were injected intravenously immediately before the procedure.
   Satisfactory sedation which made additional injection of the drug
   during the endoscopy superfluous could be achieved in 66% of the
   patients with Thalamonal and in 52% with *Valium* respectively.  The
   difference between the two preparations is statistically significant
   (p less than 0,005).  In 95 patients catamnestic studies were
   performed in order to evaluate second episodes of fatigue after the
   endoscopy.  A good effect of the preparation during endoscopy and a
   lack of second attacks of sedation following discharge was observed
   only in 23% of the patients after Thalamonal and in 21% of the
   patients after *Valium* injection, respectively.  Therfore a good
   premedication was achieved in only one fifth of the patients
   receiving one of the two drugs.  Author.
MJ DIAZEPAM.  DROPERIDOL.  ENDOSCOPY.  *FENTANYL.*  NEUROLEPTANALGESIA.
   PREMEDICATION.
MN COMPARATIVE-STUDY.  DOUBLE-BLIND-METHOD.  DUODENAL-DISEASES: di.
   ENGLISH-ABSTRACT.  ESOPHAGOSCOPY.  EVALUATION-STUDIES.  GASTROSCOPY.
   HUMAN.  INJECTIONS-INTRAVENOUS.  MIDDLE-AGE.
YR 79.
IS 0300-8622.

       5
AN 79019233.  7900.
AU Hempelmann-G.  Seitz-W.  Piepenbrock-S.
IN Institut fur Anaesthesiologie der Medizinischen Hochschule Hannover.
TI [Diazepam *(valium).*  Changes in haemodynamics, myocardial oxygen
   consumption and vascular tone (author's transl)].
TT Diazepam *(Valium).*  Ein Beitrag zu Hamodynamik, myokardialem
   Sauerstoffverbrauch und Gefasseffekt.
SO Anaesthesist. 1978 Aug. 27(8). P 357-63.
LG GE.
AB In 30 patients with congenital or acquired heart disease the
   haemodynamic effects of diazepam *(Valium)* 0.3 mg/kg were
   investigated during surgical procedures under neuroleptanalgesia.
   The following parameters were measured or calculated: Heart rate
   (HR), arterial pressure (-Part, Psyst, Pdiast), pulmonary artery
   pressure (-PAP), right (-PRA) and left atrial pressure (-PLA), left
   ventricular pressure (PLV), left ventricular enddiastolic pressure
   (PLVED), left ventricular peak dp/dt (dp/dtmax), cardiac output
   (CO), cardiac index (CI), stroke volume (SV), stroke index (SI),
   total systemic resistance (TSR), total pulmonary resistance (TPR),
   work index of the right (RVWI) and left ventricle (LVWI).  In
   comparison with a control group (n = 36) diazepam caused a decrease
   in arterial pressure cardiac index, stroke index, right and left
   atrial pressure and dp/dtmax.  This, however, was mainly
   attributable to vasodilatation and not to a negative inotropic
   effect, which is of only minor importance with diazepam.  These
   haemodynamic changes resulted in a reduction in myocardial oxygen
   consumption.  Diazepam is a valuable drug in neuroleptanalgesia,
   when an increase in blood pressure can not be controlled by *fentanyl*
   or droperidol.  Author.
MJ DIAZEPAM.  HEMODYNAMICS: de.  OXYGEN-CONSUMPTION: de.
MN BLOOD-PRESSURE: de.  BLOOD-VESSELS: de.  CARDIAC-OUTPUT: de.
   ENGLISH-ABSTRACT.  FEMALE.  HEART-DEFECTS-CONGENITAL: su.
   HEART-RATE: de.  HUMAN.  MALE.  MIDDLE-AGE.  NEUROLEPTANALGESIA.
   STROKE-VOLUME: de.  VASCULAR-RESISTANCE: de.
YR 78.
IS 0003-2417.

       6
AN 78006256.  7800.
AU Arroyo-J.
TI Intravenous sedation with sublimaze and *valium.*
SO J-Am-Podiatry-Assoc. 1977 Sep. 67(9). P 645-6.
LG EN.
MJ DIAZEPAM: ad.  *FENTANYL:* ad.  PREANESTHETIC-MEDICATION.
MN FOOT-DISEASES: su.  HUMAN.  INJECTIONS-INTRAVENOUS.
YR 77.
IS 0003-0538.

       7
AN 77234400.  7700.
AU Conradi-R.  Just-O-H.
IN Abteilung fur Anasthesiologie, der Univ.-Kliniken Heidelberg.
TI [A special technique of neurolept analgesia for thermocoagulation of
   the gasserian ganglion (author's transl)].
TT Eine spezielle Methode der Neuroleptanalgesie zur Elektrokoagulation
   des Ganglion Gasseri.
SO Prakt-Anaesth. 1977 Feb. 12(1). P 38-42.
LG GE.
AB A special technique of neurolept analgesia for electrocoagulation of
   the gasserian ganglion is described which has been used since 1974.
   Induction is by means of *Fentanyl* and *Valium.*  The dosis is
   sufficiently low for the patient to remain responsive and
   co-operative but practically painfree.  The actual thermocoagulation
   is performed in intravenous methohexital sodium anaesthesia.  The
   dosis is kept so low that the patient wakes up within 2--3 minutes
   and is able to inform the surgeon of the success or failure of the
   operation.  If no relief from pain has been obtained a further 20 mg
   of methohexital are injected and the operation is repeated.  Author.
MJ GANGLIA: su.  NEUROLEPTANALGESIA: mt.  TRIGEMINAL-NEURALGIA: su.
MN DIAZEPAM: tu.  ELECTROCOAGULATION.  ENGLISH-ABSTRACT.  *FENTANYL:* tu.
   HUMAN.  METHOHEXITAL.  PREMEDICATION.
YR 77.
IS 0302-7600.

       8
AN 77141626.  7700.
AU Alafriz-E.
TI Intravenous sedation with *Valium* and Sublimaze with the addition of
   nitrous oxide.
SO J-Am-Podiatry-Assoc. 1977 Mar. 67(3). P 187.
LG EN.
MJ DIAZEPAM.  *FENTANYL.*  NEUROLEPTANALGESIA: mt.  NITROUS-OXIDE.
MN DIAZEPAM: ad.  *FENTANYL:* ad.  FOOT: su.  HUMAN.
   INFUSIONS-PARENTERAL.
YR 77.
IS 0003-0538.

       9
AN 77129068.  7700.
AU Cox-H-D.  Deshon-G-E.  Mittemeyer-B-T.  Condon-B.  Balance-D.
IN Department of Urology, Walter Reed General Hospital, Washington, D.
   C.
TI Ataralgesia in outpatient urology.  Clinical evaluation.
SO Urology. 1977 Feb. 9(2). P 164-9.
LG EN.
AB The combination of *fentanyl* citrate (Sublimaze) and diazepam
   *(Valium)* was evaluated for efficacy of analgesia, sedation, and
   safety in 1,008 predominately outpatient urologic procedures.  These
   procedures included prostate biopsies, basket extractions of
   ureteral calculi, internal urethrotomies, and cystourethroscopies.
   Ninety-two per cent were judged to be successful with regard to
   adequate tranquilization and relief of pain.  No detrimental effects
   were seen with the recommmended method and dosage.  This drug
   combination provides the clinician with an effective and safe
   alternative to local, general, or spinal anesthesia for many routine
   urologic procedures and allows them to becom true office procedures.
   Author.
MJ DIAZEPAM: ad.  *FENTANYL:* ad.  NEUROLEPTANALGESIA.
   UROLOGIC-DISEASES.
MN ADOLESCENCE.  ADULT.  AGED.  DIAZEPAM: pd.  DRUG-THERAPY-COMBINATION.
   FEMALE.  *FENTANYL:* ae, me.  HUMAN.  MALE.  MIDDLE-AGE.
   OUTPATIENT-CLINICS-HOSPITAL.
YR 77.
IS 0090-4295.

      10
AN 75157094.  7500.
AU Wesseling-H.  Kruizinga-P-J.  Leezenberg-J-A.
TI Diazepan *(Valium)* compared with other premedications in
   tonsillectomy, nasal septum correction and endoscopy under local
   anaesthesia.
SO ORL-J-Otorhinolaryngol-Relat-Spec. 1974. 36(6). P 383-92.
LG EN.
MJ ANESTHESIA-LOCAL.  DIAZEPAM.  ENDOSCOPY.  NASAL-SEPTUM: su.
   PREANESTHETIC-MEDICATION.  TONSILLECTOMY.
MN BARBITURATES: pd.  BLOOD-PRESSURE: de.  BRONCHOSCOPY.
   CLINICAL-TRIALS.  COMPARATIVE-STUDY.  DIAZEPAM: ae, pd.  DROPERIDOL:
   pd.  DRUG-COMBINATIONS.  ESOPHAGOSCOPY.  *FENTANYL:* pd.  HEART-RATE:
   de.  HUMAN.  LARYNGOSCOPY.  MENTAL-PROCESSES: de.  MEPERIDINE: pd.
   PLACEBOS.  PROMETHAZINE: pd.  TRIFLUPROMAZINE: pd.
YR 74.
IS 0301-1569.

      11
AN 70190346.  7000.
AU Mulder-J-A.
TI [Valium-fentanyl, a black swan?].
TT Valium-fentanyl, een witte raaf?.
SO Ned-Tijdschr-Geneeskd. 1970 May 23. 114(21). P 867-9.
LG DU.
MJ DIAZEPAM.  *FENTANYL.*  NEUROLEPTANALGESIA.
MN BENPERIDOL: ae.  DRUG-SYNERGISM.  ENGLISH-ABSTRACT.  HUMAN.  MUSCLES:
   de.
YR 70.
IS 0028-2162.

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       1
AN 80239912.  8000.
AU Huse-K.  Schaffer-R.  Fistas-G.
IN Institut fur Anasthesiologie der Universitat, Dusseldorf.
TI [Clinical experiences with diazepam *(Valium)* - *fentanyl* combination
   anesthesia in neurosurgery.  A study of circulation and oxygen
   consumption].
TT Klinische Erfahrungen mit der
   Diazepam-(Valium)-Fentanyl-Kombinationsnarkose in der Neurochirurgie.
   Untersuchungen des Kreislaufs und des Sauerstoffverbrauchs.
SO Anasth-Intensivther-Notfallmed. 1980 Apr. 15(2). P 135-43.
LG GE.
AB This clinical study was performed on 13 neurosurgical patients.  The
   mean age was 56 years (range 45-70 years).  After induction of
   anesthesia the heart rate diminished by 21.4%, the mean pressure by
   12.2% in the same time decreased the cardiac output by 19.3%, the
   calculated total peripheral resistance increased by 13%.  The oxygen
   uptake decreased by 16%.  The advantages and contraindications of
   this technique in neuroanesthesia are discussed.  Author.
MJ DIAZEPAM: ad.  *FENTANYL:* ad.  HEMODYNAMICS: de.  NERVOUS-SYSTEM: su.
   OXYGEN-CONSUMPTION: de.
MN AGED.  BLOOD-PRESSURE: de.  CARBON-DIOXIDE: bl.  CARDIAC-OUTPUT: de.
   DRUG-THERAPY-COMBINATION.  ENGLISH-ABSTRACT.  FEMALE.  HEART-RATE:
   de.  HUMAN.  MALE.  MIDDLE-AGE.  VASCULAR-RESISTANCE: de.
RN 437-38-7 -- *Fentanyl.*
   439-14-5 -- Diazepam.
YR 80.
IS 0174-1837.

       2
AN 77234400.  7700.
AU Conradi-R.  Just-O-H.
IN Abteilung fur Anasthesiologie, der Univ.-Kliniken Heidelberg.
TI [A special technique of neurolept analgesia for thermocoagulation of
   the gasserian ganglion (author's transl)].
TT Eine spezielle Methode der Neuroleptanalgesie zur Elektrokoagulation
   des Ganglion Gasseri.
SO Prakt-Anaesth. 1977 Feb. 12(1). P 38-42.
LG GE.
AB A special technique of neurolept analgesia for electrocoagulation of
   the gasserian ganglion is described which has been used since 1974.
   Induction is by means of *Fentanyl* and *Valium.*  The dosis is
   sufficiently low for the patient to remain responsive and
   co-operative but practically painfree.  The actual thermocoagulation
   is performed in intravenous methohexital sodium anaesthesia.  The
   dosis is kept so low that the patient wakes up within 2--3 minutes
   and is able to inform the surgeon of the success or failure of the
   operation.  If no relief from pain has been obtained a further 20 mg
   of methohexital are injected and the operation is repeated.  Author.
MJ GANGLIA: su.  NEUROLEPTANALGESIA: mt.  TRIGEMINAL-NEURALGIA: su.
MN DIAZEPAM: tu.  ELECTROCOAGULATION.  ENGLISH-ABSTRACT.  *FENTANYL:* tu.
   HUMAN.  METHOHEXITAL.  PREMEDICATION.
YR 77.
IS 0302-7600.

       3
AN 77129068.  7700.
AU Cox-H-D.  Deshon-G-E.  Mittemeyer-B-T.  Condon-B.  Balance-D.
IN Department of Urology, Walter Reed General Hospital, Washington, D.
   C.
TI Ataralgesia in outpatient urology.  Clinical evaluation.
SO Urology. 1977 Feb. 9(2). P 164-9.
LG EN.
AB The combination of *fentanyl* citrate (Sublimaze) and diazepam
   *(Valium)* was evaluated for efficacy of analgesia, sedation, and
   safety in 1,008 predominately outpatient urologic procedures.  These
   procedures included prostate biopsies, basket extractions of
   ureteral calculi, internal urethrotomies, and cystourethroscopies.
   Ninety-two per cent were judged to be successful with regard to
   adequate tranquilization and relief of pain.  No detrimental effects
   were seen with the recommmended method and dosage.  This drug
   combination provides the clinician with an effective and safe
   alternative to local, general, or spinal anesthesia for many routine
   urologic procedures and allows them to becom true office procedures.
   Author.
MJ DIAZEPAM: ad.  *FENTANYL:* ad.  NEUROLEPTANALGESIA.
   UROLOGIC-DISEASES.
MN ADOLESCENCE.  ADULT.  AGED.  DIAZEPAM: pd.  DRUG-THERAPY-COMBINATION.
   FEMALE.  *FENTANYL:* ae, me.  HUMAN.  MALE.  MIDDLE-AGE.
   OUTPATIENT-CLINICS-HOSPITAL.
YR 77.
IS 0090-4295.

       4
AN 70190346.  7000.
AU Mulder-J-A.
TI [Valium-fentanyl, a black swan?].
TT Valium-fentanyl, een witte raaf?.
SO Ned-Tijdschr-Geneeskd. 1970 May 23. 114(21). P 867-9.
LG DU.
MJ DIAZEPAM.  *FENTANYL.*  NEUROLEPTANALGESIA.
MN BENPERIDOL: ae.  DRUG-SYNERGISM.  ENGLISH-ABSTRACT.  HUMAN.  MUSCLES:
   de.
YR 70.
IS 0028-2162.

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