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- *******************************************************
- * Translationally controlled tumor protein signatures *
- *******************************************************
-
- The mammalian translationally controlled tumor protein (TCTP) is a protein
- which has been found to be preferentially synthesized in cells of the early
- growth phase some type of tumors [1,2], but which is also expressed in normal
- cells. The physiological function of TCTP is still not known. It is a
- hydrophilic protein of 172 amino acid residues. Close homologs of TCTP have
- been found in plants [3,4,5] and in yeast [6].
-
- As signature patterns for TCTP, we selected two of the best conserved regions.
-
- -Consensus pattern: I-G-[GA]-N-[PAG]-S-A-E-G-[PAG]-x(0,1)-[DE]-x-[DE]-x(2)-
- [DE]
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
-
- -Consensus pattern: F-F-x-G-E-x-M-x(2)-D-[GA]-x-[LIVM]
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
-
- -Last update: June 1994 / First entry.
-
- [ 1] Boehm H., Beendorf R., Gaestel M., Gross B., Nuernberg P., Kraft R.,
- Otto A., Bielka H.
- Biochem. Int. 19:277-286(1989).
- [ 2] Makrides S., Chitpatima S.T., Bandyopadhyay R., Brawerman G.
- Nucleic Acids Res. 16:2350-2350(1988).
- [ 3] Pay A., Heberle-Bors E., Hirt H.
- Plant Mol. Biol. 19:501-503(1992).
- [ 4] Mache R., Quigley F., Thomas F., Yu D.Y.
- EMBL/GenBank: Z18387.
- [ 5] Nishi R., Uchimiya H., Kato A.
- EMBL/GenBank: D12626.
- [ 6] Rasmussen S.W.
- Yeast In press(1994).
-