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- *****************************************
- * glpT family of transporters signature *
- *****************************************
-
- The following bacterial proteins involved in the uptake of phosphorylated
- metabolites, are evolutionary related [1,2]:
-
- - Escherichia coli glycerol-3-phosphate transporter (gene glpT).
- - Salmonella typhimurium phosphoglycerate transporter (gene pgtP).
- - Escherichia coli and Salmonella typhimurium hexose-6-phosphate transporter
- (gene uhpT).
- - Escherichia coli and Salmonella typhimurium protein uhpC. UhpC is necessary
- for the expression of uhpT and seems to act jointly with the uhpB sensor/
- kinase protein.
-
- These proteins of about 50 Kd apparently contain 12 transmembrane regions. As
- a signature pattern we selected a conserved region in their central section.
-
- -Consensus pattern: R-G-x(5)-W-N-x(2)-H-N-x-G-G
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
- -Last update: June 1994 / First entry.
-
- [ 1] Goldrick D., Yu G.-Q., Jiang S.-Q., Hong J.-S.
- J. Bacteriol. 170:3421-3426(1988).
- [ 2] Marger M.D., Saier M.H. Jr.
- Trends Biochem. Sci. 18:13-20(1993).
-