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- * ATP synthase delta (OSCP) subunit signature *
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-
- ATP synthase (proton-translocating ATPase) (EC 3.6.1.34) [1,2] is a component
- of the cytoplasmic membrane of eubacteria, the inner membrane of mitochondria,
- and the thylakoid membrane of chloroplasts. The ATPase complex is composed of
- an oligomeric transmembrane sector, called CF(0), which acts as a proton
- channel, and a catalytic core, termed coupling factor CF(1).
-
- One of the subunits of the ATPase complex, known as subunit delta in bacteria
- and chloroplasts or the Oligomycin Sensitivity Conferral Protein (OSCP) in
- mitochondria, seems to be part of the stalk that links CF(0) to CF(1). It
- either transmits conformational changes from CF(0) into CF(1) or is involved
- in proton conduction [3].
-
- The different delta/OSCP subunits are proteins of approximately 200 amino-acid
- residues - once the transit peptide has been removed in the chloroplast and
- mitochondrial forms - which show only moderate sequence homology.
-
- The signature pattern used to detect ATPase delta/OSCP subunits is based on a
- conserved region in the C-terminal section of these proteins.
-
- -Consensus pattern: [LIVM]-x-[LIVMT]-x(3)-[LIVMT]-[DNK]-x(2)-[LIVM]-x-[GA]-G-
- [LIVMFYGA]-x-[LIVM]-[KREQ]-x-[GN]
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
- -Last update: June 1994 / Pattern and text revised.
-
- [ 1] Futai M., Noumi T., Maeda M.
- Annu. Rev. Biochem. 58:111-136(1989).
- [ 2] Senior A.E.
- Physiol. Rev. 68:177-231(1988).
- [ 3] Engelbrecht S., Junge W.
- Biochim. Biophys. Acta 1015:379-390(1990).
-