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- ******************************************************
- * Eukaryotic initiation factor 5A hypusine signature *
- ******************************************************
-
- Eukaryotic initiation factor 5A (eIF-5A) (formerly known as eIF-4D) [1,2] is a
- small protein whose precise role in the initiation of protein synthesis is not
- known. It appears to promote the formation of the first peptide bond. eIF-5A
- seems to be the only eukaryotic protein to contain an hypusine residue.
- Hypusine is derived from lysine by the post-translational addition of a
- butylamino group (from spermidine) to the epsilon-amino group of lysine. The
- hypusine group is essential to the function of eIF-5A.
-
- A hypusine-containing protein has been found in the archaebacteria Sulfolobus
- acidocaldarius; this protein is highly similar to eIF-5A and could play a
- similar role in protein biosynthesis.
-
- The signature we developed for eIF-5A is centered around the hypusine residue.
-
- -Consensus pattern: T-G-K-H-G-x-A-K
- [The first K is modified to hypusine]
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
- -Last update: June 1994 / Text revised.
-
- [ 1] Park M.H., Wolff E.C., Folk J.E.
- Biofactors 4:95-104(1993).
- [ 2] Schnier J., Schwelberger H.G., Smit-McBride Z., Kang H.A., Hershey J.W.B.
- Mol. Cell. Biol. 11:3105-3114(1991).
-