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- ******************************************************
- * Manganese and iron superoxide dismutases signature *
- ******************************************************
-
- Manganese superoxide dismutase (EC 1.15.1.1) (SODM) [1] is one of the three
- forms of an enzyme that catalyzes the dismutation of superoxide radicals. The
- four ligands of the manganese atom are conserved in all the known SODM
- sequences. These metal ligands are also conserved in the related iron form of
- superoxide dismutases [2,3]. We selected, as a signature, a short conserved
- region which includes two of the four ligands: an aspartate and a histidine.
-
- -Consensus pattern: D-x-W-E-H-[STA]-[FY](2)
- [D and H are manganese/iron ligands]
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: NONE.
- -Last update: June 1992 / Text revised.
-
- [ 1] Bannister J.V., Bannister W.H., Rotilio G.
- CRC Crit. Rev. Biochem. 22:111-154(1987).
- [ 2] Parker M.W., Blake C.C.F.
- FEBS Lett. 229:377-382(1988).
- [ 3] Smith M.W., Doolittle R.F.
- J. Mol. Evol. 34:175-184(1992).
-