Karl, Beethoven's nephew tries to commit suicide by shooting himself in the head. As one who had conquered fate, this had a shattering effect on Beethoven.
@Beethoven Forgives Karl@2
Beethoven wrote to Karl: "...All is forgiven and forgotten. Never think that I am dominated by any other thought but that of your well-being...Whatever you do, do not take any steps which will make you unhappy and kill me before my time..."
@Last Quartet@2
"Here, my dear friend", Beethoven writes to M. Schlesinger, "is my last quartet. It will be the last, and indeed it has given me much trouble." This was Op. 135.