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- Newsgroups: sci.med,sci.med.nutrition
- Path: sparky!uunet!newsserver.pixel.kodak.com!sasquatch!young
- From: young@serum.kodak.com (Rich Young)
- Subject: Fat cravings
- Message-ID: <1992Nov10.171237.11985@pixel.kodak.com>
- Originator: young@sasquatch
- Sender: news@pixel.kodak.com
- Reply-To: young@serum.kodak.com
- Organization: Clinical Diagnostics Division, Eastman Kodak Company
- Date: Tue, 10 Nov 92 17:12:37 GMT
- Lines: 40
-
- From SCIENCE NEWS: Vol. 142, No. 19, November 7, 1992, page 311 (quoted with-
- out permission and edited for brevity):
-
- A team of neuroscientists led by Sarah F. Leibowitz at Rockefeller
- University in New York City has uncovered evidence in rats that a
- brain protein called galanin dictates the craving for fatty foods.
- Moreover, the group has found that a drug that blocks galanin's
- activity can reduce an animal's appetite for fat.
- Leibowitz's team found that rats with high natural concentrations
- of galanin in a brain region called the hypothalamus at more lard
- each day and gained more weight over the study period than did rats
- with low galanin concentrations -- despite the fact that both groups
- consumed roughly the same amount of protein and carbohydrate each
- day. In addition, the researchers observed, the rats with high
- galanin levels almost always began their meals by lapping up lard,
- indicating that they might be trying to satisfy a craving.
- In a second study reported at the [Society for Neuroscience's
- annual meeting], Leibowitz' group ruled out the possibility that
- the extra galanin might have arisen elsewhere in the rats' bodies
- and then traveled to their brains. They also found that [rats with
- high galanin concentrations] had reduced concentrations of insulin
- in the blood, indicating that galanin serves as a biochemical link
- between obesity and diabetes. Her team has not yet determined how
- galanin and insulin interact.
- Leibowitz [says] that earlier experiments by her group and others
- have shown that rats receiving galanin injections in a specific
- region of their hypothalamus eat much more fat than do control rats
- given galanin injections elsewhere in their brains. Moreover, she
- says, the galanin injections make the fat-gobbling rats sluggish,
- reducing their metabolism and leading to weight gain.
- Leibowitz and her colleagues have recently fouond that an experi-
- mental drug called M40 can slash a rat's fat craving by blocking
- the activity of galanin in its hypothalamus. In the November/
- December BRAIN RESEARCH, she and Rockefeller colleague Taewan Kim
- report that rats given extra galanin to boost their fat intake
- resume eating normal amounts of fat following injections of M40.
-
-
-
- -Rich Young (These are not Kodak's opinions.)
-