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- Subject: ATN #167
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- J O H N J A M E S writes on A I D S
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- Copyright 1993 by John S. James; permission granted for non-commercial
- use.
-
- AIDS TREATMENT NEWS Issue #167, January 15, 1993
- phone 800/TREAT-1-2, or 415/255-0588
-
- CONTENTS:
-
- Announcements:
-
- Oral Ganciclovir Prophylaxis Study Recruiting
-
- New York: Hypericin Trial Recruiting, P24 No Longer
- Necessary
-
- San Francisco, Salt Lake City: Acyclovir-Resistant Herpes
- Simplex Trial
-
- Tat Inhibitor Support Group Forming -- Baltimore, Boston,
- Cleveland, San Diego
-
- San Francisco: Conference on Speech, Hearing, and Vision
- Loss, February 26
-
- San Francisco: "Caring for HIV Naturally" Four-Part Forum
-
- AIDS Czar Issue: Report to President, or Report to HHS?
-
- Resource List, January 1993: Activist Groups, Buyers' Clubs,
- and PWA Coalitions
-
- ***** ddI vs. AZT: New Results, No Press
- by Larry Tate
-
- For months, AIDS researchers have eagerly awaited the results of a
- major clinical trial ACTG 116A, comparing AZT with two different doses
- of ddI in volunteers with little or no previous antiviral treatment.
- Results were released on December 30 by the National Institute of
- Allergies and Infectious Diseases (NIAID). This study had been expected
- to tell which of these FDA-approved drugs was better for "first- line"
- therapy -- the drug given to people to begin treatment and continued,
- traditionally, until it becomes less effective. But the study gave a
- complex answer to this question -- or perhaps answered a different
- question.
-
- There has been little or no press coverage of the NIAID
- announcement. But ACTG 116A found major differences in survival and in
- disease progression depending on how the antivirals were used; as a
- result, this trial will influence thinking among patients, physicians
- and researchers for some time. For this reason, and because it is
- difficult for the public to get much information about the trial at
- this time, AIDS TREATMENT NEWS decided to cover the results in some
- detail.
-
- According to a NIAID statement, "the primary finding of the study
- was that the relative efficacy of ddI and AZT depends upon the duration
- of prior AZT therapy. Generally, AZT appeared to be more efficacious
- than ddI among patients who were AZT-naive at study entry, while ddI
- appeared more efficacious than AZT among those who were AZT-experienced,
- particularly those who had 8-16 weeks of prior AZT. This phenomenon was
- observed both for the primary endpoint of time to new AIDS-defining
- event or death, and the secondary endpoint of survival." The group with
- the best results of any in the study was the one that started ddI after
- 8-16 weeks of AZT use.
-
- ACTG 116A clarifies and extends last year's results from ACTG
- 116B/117, which compared the same ddI doses to AZT in people with prior
- AZT use of at least 16 weeks (with a median duration of about one year).
- That study showed a clear advantage for ddI in delaying disease
- progression, and the current FDA labeling of ddI reflects that finding,
- recommending ddI after "prolonged" AZT use. However, the earlier study
- did not show a clear survival advantage for ddI.
-
- The Trial
-
- ACTG 116A began in 1989 and ended in May 1992; volunteers wereeks.
- The trial was conducted at 38 sites, mostly centers of the AIDS Clinical
- Trial Group (ACTG). It included 617 people who either (1) had AIDS or
- advanced ARC and fewer than 300 T-helper cells, or (2) had asymptomatic
- HIV infection and fewer than 200 T- helper cells.
- [Note: the term ARC -- AIDS-related complex -- is now obsolete; ACTG
- 116A was designed several years ago.]
-
- The volunteers were randomly assigned into three arms: ddI 500 mg
- per day, ddI 750 mg per day, or the standard dose of AZT. (The ddI was
- given in powder form; 500 mg of the powder equals 400 mg of the better-
- absorbed tablets, which are now most often used. The ddI doses "were
- reduced by one third for patients weighing less than 60 kg [132
- pounds].")
-
- Disease "progression" was defined, as in the earlier study, as
- either the occurrence of a new AIDS-defining event or death.
-
- Among 380 people without prior AZT, 29 percent of those on 500
- mg/day of ddI progressed to more serious illness or death; 31 percent
- progressed at 750 mg/day ddI; but only 18 percent of the AZT arm
- progressed, a statistically significant advantage for AZT.
- ["Statistically significant" means that this big a difference in results
- would be unlikely to occur by chance alone, if there were really no
- difference in how well the drugs worked.]
-
- Among the 119 people with some prior AZT use but no more than eight
- weeks, there was a small trend in favor of AZT, but it was not
- statistically significant.
-
- However, among 118 people with 8-16 weeks of prior AZT use, one
- year progression rates were 11 percent for 500 mg of AZT, 17 percent for
- 750 mg, but 33 percent with AZT -- a statistically significant advantage
- for ddI.
-
- In contrast to the results of the related study reported last year
- (ACTG 116B/117), the new survival statistics from ACTG 116A generally
- reflected progression statistics. For people with no prior AZT, AZT
- showed a clear advantage in survival; one-year death rates were 10
- percent for 500 mg of ddI and nine percent for 750 mg, but only four
- percent for AZT. For people with up to eight weeks of prior AZT, there
- was no significant difference in survival rates. But for people with
- eight to 16 weeks of prior AZT, ddI showed a clear survival advantage
- (one-year death rates three percent for 500 mg of ddI, and two percent
- for 750 mg, compared to 11 percent for AZT). [The small differences in
- survival rates between the two ddI doses are not statistically
- significant, and could easily have occurred by chance.]
-
- The primary side effect of AZT was granulocytopenia (low white cell
- counts). Primary ddI side effects were pancreatitis and peripheral
- neuropathy. Two volunteers in the study died of pancreatitis; both were
- on the 750 mg ddI dose. The rate of pancreatitis at the lower ddI dose
- was seven percent, compared to four percent among the volunteers
- originally assigned to AZT, a difference which was not statistically
- significant. This finding agrees with that of 116B/117, and should
- reduce the long-standing fear (based on reports from the early ddI
- expanded-access program) that pancreatitis is a likely result of ddI
- use.
-
- Analysis
-
- The results of this study are surprising, and not easy to
- interpret. They will be much discussed and analyzed in the months to
- come. When ACTG 116A started, it was expected that people with no prior
- AZT and people with 16 weeks of prior AZT would turn out to respond
- about the same. The decisiveness of relatively small differences in
- prior AZT duration was not foreseen.
-
- It seems puzzling that people starting therapy on the standard ddI
- dose will experience a 29 percent one-year progression rate, while
- giving people 8 weeks of AZT before starting them on the same ddI dose
- will reduce that to 11 percent. The study seems to show that this
- short course of AZT before switching contributes dramatically to the
- subsequent efficacy of ddI and to the over-all efficacy of therapy (the
- lowest progression rate on a single drug was 18 percent, in people who
- received only AZT), but it doesn't show why. There are speculations
- about intracellular mechanisms, but there is as yet no agreement on what
- they might be.
-
- For people with longer-term AZT use (as in the study reported last
- year, 116B/117) it might be reasonable to suppose that AZT resistance
- contributes to the added efficacy of switching to ddI; however, in the
- short-term use allowed in 116A, it is unlikely that resistance is a
- significant factor.
-
- Perhaps 116A does not really show what it seems to show. According
- to a NIAID summary, "The trial was not designed to test the hypothesis
- that switching to ddI after at least 8 weeks of AZT is an appropriate
- monotherapy strategy for AZT- naive patients with advanced HIV
- infection. Although the data are consistent with this hypothesis, there
- are other possible explanations for the treatment differences observed
- in the group with 8-16 weeks of prior AZT. A particular concern is that
- this group may not be representative of all patients with 8-16 weeks of
- prior AZT because many patients who felt they were benefiting from AZT
- may have elected not to enter ACTG 116A. "But it is thought unlikely
- that this concern would account for the important differences that were
- seen.
-
- There are other uncertainties which might have affected the results
- of the study. (1) A number of volunteers dropped out of the trial,
- possibly biasing it in some way. (2) There was a 20 percent crossover
- rate, which refers to people who started on one drug but then switched
- to the other after problems arose. [Under the "intent to treat"
- analysis used for this trial, they were counted in the final analysis
- as if they had stayed on the first drug, even though they actually
- switched. The reason for this seemingly bizarre procedure is that
- researchers often want to measure the effect of the decision to treat
- with one drug or the other (which may differ from the treatment that
- actually is delivered) -- since only the decision is directly under the
- physician's and patient's control.] (3) For a few months at the
- beginning of the study the AZT group was receiving the old dose of 1200
- mg per day, which could have affected the side-effect rate for that
- group -- a rate that was higher than the ddI rate and could have caused
- more people to switch to ddI than to AZT. (4) The differences in
- survival rates, NIAID cautions, may be affected by the lack of long-term
- follow-up for more people in the AZT group than in the ddI groups, since
- some deaths could have been missed. (5) The people in the AZT-naive
- group tended to start with lower T-helper counts than the people in the
- AZT- experienced groups, but AZT-experienced people more often had an
- AIDS diagnosis -- two potential biases, but fortunately in the opposite
- direction. (6) The study was originally intended to be larger, but
- recruiting problems caused the 500 mg ddI arm to be closed prematurely,
- so that comparisons between that arm and the other two have, according
- to NIAID, "slightly reduced statistical power." It may not be possible
- to say if or how these and other factors affected the study's outcome.
-
- On balance, however, the study results are more likely to be
- accepted as further confirmation of the broader trend in findings on HIV
- antiretrovirals, i.e., that no single drug, given for an indefinite
- period, is likely to be the most effective treatment strategy. The
- NIAID summary notes, "If a patient does switch from AZT to ddI, it is
- not known whether returning to AZT or remaining on ddI is more
- appropriate. Future trials will be required to assess the value of
- alternating regimens."
-
- There have already been various small studies looking at
- alternating regimens, and the results suggest that future treatment
- strategies are likely to center not on alternating antiretrovirals but
- on combining them. A small study presented at last year's International
- AIDS Conference (and soon to be published) directly compared a group of
- volunteers alternating AZT and ddI to a group combining them, and found
- decisive superiority for the combination group. A researcher involved in
- ACTG 116A says that, by showing the added value of using more than one
- drug, this study (116A) could be interpreted as providing further
- support for the idea of combination therapy. And a press statement from
- Burroughs- Wellcome (maker of AZT) notes, "The data from 116A must be
- placed in the perspective of the emerging consensus that combination
- therapy will play an increasingly critical role in the management of HIV
- disease." [As noted in the last issue of AIDS TREATMENT NEWS, new
- information on various combination therapies will become known
- throughout this year and next year.]
-
- Still, official recommendations favoring combination therapy will
- probably not come soon; and NIAID pointedly made no recommendations, on
- the basis of 116A, about switching from one drug to another after 8
- weeks. The clinician and patient, looking at the findings of 116A, may
- not know what guidance, if any, can be taken from it.
-
- In the near future there may be a meeting of treatment experts to
- arrive at an interpretation of this study's findings. In case a
- consensus is reached that switching drugs after relatively short periods
- of first-line therapy is the best treatment strategy, every HIV doctor
- and most HIV patients would be directly affected. Not only clinical
- practice but some ongoing clinical trials would need to be rethought.
- Dr. Laurie Smaldone (a member of the study team) says, "This is a very
- important study and everyone recognizes it."
-
- A spokesperson for Bristol-Myers (maker of ddI) says that, although
- timetables and details are undecided, the company will seek expanded FDA
- labeling for ddI based on 116A. The current labeling indicates
- switching to ddI after "prolonged" AZT use; 8 weeks is far from a
- "prolonged" period.
-
- In sum, a study that had been expected to tell which drug, AZT or
- ddI, is the better single-drug therapy may, instead, be providing
- further evidence that treatment with either single drug -- particularly
- when continued indefinitely without switching drugs -- is probably an
- idea whose time is passing.
-
- ***** CMV Experimental Treatment Overview (Part I)
-
- by Giacomo egalovirus (CMV) is a virus which infects much of the general
- population, and most persons with HIV. CMV rarely causes disease,
- however, unless the immune system is suppressed -- as in recipients of
- organ transplants who must take immunosuppressive drugs, or in persons
- with AIDS. Those with T-helper counts under 50 are at greatest risk of
- CMV disease, although it can occur at higher T-helper counts.
-
- CMV retinitis, an infection of the retina of the eye which causes
- blindness if untreated, occurs in 10 to 20 percent of people with AIDS
- in the United States. CMV retinitis accounts for about 80 percent or
- more of CMV disease in persons with AIDS. One eye is usually affected
- first, and a two or three week intensive "induction" treatment with an
- anti-CMV drug (ganciclovir or foscarnet, see below) is necessary to save
- its sight. After the induction phase, patients are put on a lower
- "maintenance" dose of one of the drugs, to prevent the retinitis from
- continuing to progress. If the person does not use the maintenance
- therapy, the retinitis will also affect the other eye within six months
- in roughly 60 percent of the cases; with maintenance therapy, this is
- reduced to about 15 percent.
-
- CMV can also cause disease in the lungs, colon, adrenals,
- esophagus, and other organs.
-
- Because CMV retinitis can rapidly cause permanent vision loss,
- persons with T-helper counts less than 200 should have regular eye
- examinations, and must get medical attention immediately if vision
- problems develop. (Although retinitis rarely occurs when T-helper
- counts are above 50, there are other reasons for persons with AIDS to
- have eye examinations; also, if retinitis occurs, it is important to
- have already established a relationship with a CMV-knowledgeable
- ophthalmologist.) While exposure to CMV can be detected by a test for
- antibodies in the blood, this test does not tell whether or when CMV
- disease will occur.
-
- Two drugs -- ganciclovir and foscarnet -- have been approved by the
- FDA for treating CMV retinitis by intravenous administration. While
- known to be effective, both have serious drawbacks, and a number of
- experimental treatments in various stages of development are being
- tried. This article will look at new ways to use the standard
- treatments, as well as experimental CMV treatments which are now being
- developed.
-
- Ganciclovir; Use of G-CSF or GM-CSF
-
- Ganciclovir (brand name Cytovene; formerly called DHPG) has been
- approved for CMV retinitis since 1990 (it is still being tested for CMV
- colitis). When retinitis is first diagnosed, the patient receives twice
- daily infusions of ganciclovir for two to three weeks (induction
- therapy), and is then put on lower daily doses for maintenance. Without
- the maintenance therapy, the retinitis may recur within a short period
- of time. (An easier dosage schedule of three infusions every week for
- maintenance therapy is currently being tested.)
-
- Because ganciclovir is toxic to neutrophils (a class of infection-
- fighting white blood cells), blood tests must be carefully monitored.
- Ganciclovir-induced neutropenia (lack of enough neutrophils) can be life
- threatening; fortunately it is usually reversible within a few days of
- stopping therapy.
-
- Since continuing CMV treatment is necessary, the best approach may
- be to avoid or neutropenia by using either G-CSF (Neupogen) or GM-CSF
- (Leukine). Both of these are substances produced by the body which
- stimulate the growth of neutrophils. In one study presented at the
- Eighth International Conference on AIDS in Amsterdam, patients were
- randomized into a group which received ganciclovir alone, and another
- group which received ganciclovir plus GM-CSF. Eighteen percent of the
- patients receiving the combination developed neutropenia, compared to 45
- percent of the patients receiving ganciclovir alone (abstract #MoA
- 0005).
-
- Both G-CSF and GM-CSF are FDA-approved for treating low neutrophil
- counts in other situations, but they are still being tested for
- combination therapy with ganciclovir, so there is no official approval
- yet, even though the drugs are in widespread use for this purpose and it
- is clear that they can be effective. For now, these drugs must be
- prescribed off label (meaning that while the FDA has approved the drug,
- it has not specifically approved that particular use). Unfortunately,
- there are still many physicians who will not prescribe these drugs off
- label, even in severe cases of neutropenia. Insurance reimbursement can
- also be a problem.
-
- Ganciclovir Eye Implants
-
- Another approach to limiting the toxicity of ganciclovir is a new
- drug delivery system now being tested at the New England Eye Center of
- the New England Medical Center, and at the University of Texas
- Southwestern Medical Center in Dallas. In these trials, a tiny time-
- release capsule containing ganciclovir is surgically implanted into the
- eye. Two eye- implant systems are being investigated. One slowly seeps
- ganciclovir into the eye for 120 days, and the other system seeps
- ganciclovir for 240 days. According to Jay Duker, M. D., Director of
- Vitreoretinal Service of the New England Eye Center, "the success rate
- with both the 4-month implant and 8-month implant is running about 90 to
- 93%. What that means is that in the patients who immediately respond to
- treatment, we have not had anyone reactivate with CMV retinitis as long
- as there's medication left in the implant. We have had a certain
- percentage, maybe ten percent, who have not responded at all to the
- implant. So there are some patients who will not respond, but in the
- ones that do seem to respond very well." One of the reasons for the
- success of this drug delivery system is that it allows for a constant
- rate of release of ganciclovir into the eye, while the amount of
- intravenous ganciclovir peaks after slightly more than an hour, but then
- leaves the eye without high levels until the next dose.
-
- Phase III trials of this drug-delivery system will begin in the
- first few months of 1993 at the New England Eye Center, and at nine
- other sites across the country. There will probably be three protocols
- in these phase III trials. One will be for newly diagnosed individuals
- with CMV retinitis and will compare the 4- month implant, the 8-month
- implant, and intravenous ganciclovir. The second protocol will be for
- individuals failing intravenous therapy (foscarnet or ganciclovir) and
- will compare the options of continuing on intravenous drug alone, or
- continuing intravenous therapy with an implant. A third trial would be
- for compassionate use of the drug delivery system.
-
- Kevin Frost, a treatment activist with ACT UP/New York and TAG
- (Treatment Action Group) who has worked on the development of these
- protocols for almost a year, said that he "firmly believes we will have
- a compassionate use protocol." One problem with a drug delivery system
- that must be surgically implanted is that a surgeon trained in the
- technique must do the procedure, so the compassionate use protocol will
- probably be limited to the 10 sites across the U. S. where the phase III
- trial will take place. Another problem is insurance or Medicaid
- reimbursement for the cost of the surgery. According to Kevin Frost,
- "when you start talking about this in terms of cost effectiveness and
- Medicaid looks at it in terms of cost-effectiveness, there's absolutely
- no question that it's cheaper to use the drug delivery system [compared
- to the alternative of daily intravenous infusions]. As a matter of
- fact, the Medicaid agencies in New York and Texas have already agreed to
- pay for the procedure. My hope is that the national Medicaid program
- will agree to pay for it within the next couple of months -- we will be
- going to work on this very issue when the protocol is approved by the
- FDA. "The phase III trial will probably take 6 to 9 months to enroll
- patients and, because the implant lasts 8 months, it will take another 8
- months before the trial closes. Then the data will have to be presented
- to the FDA for drug approval. Hopefully, the company that produces this
- device will make it available by compassionate use to those individuals
- who have CMV retinitis that is progressing, but do not meet the
- eligibility criteria of the trial.
-
- The main risks with the eye implant are those associated with
- surgery: hemorrhaging and infection. The incision line is small and not
- visible without a close inspection of the eye. There is also a danger of
- retinal detachment, but cases of detachment in the study appear to be
- due to the disease process and not the drug-delivery system. Another
- risk in administering ganciclovir this way is that CMV infection is
- often systemic (in other organs in the body, not only in the eye), and
- other parts of the body would not benefit from the eye implants.
-
- It is also possible to inject ganciclovir directly into the eye,
- although this method does not maintain a constant high level within the
- eye like the implants described above.
- Oral Ganciclovir
-
- An oral version of ganciclovir, which would be much more convenient
- than the intravenous drug and less expensive to administer, is currently
- being investigated as a treatment for CMV retinitis at 22 sites across
- the U. S. Oral ganciclovir has a bioavailability of six to ten percent
- (meaning that only that fraction is absorbed when the drug is taken
- orally). In this trial patients are randomized to either 1000 mg three
- times a day or 500 mg six times a day of oral ganciclovir. The efficacy
- of these regimens is being compared to that of a third arm in which the
- patients receive IV ganciclovir at a dose of 5 mg/kilogram of body
- weight every day.
-
- Clinical trials of oral ganciclovir as a CMV prophylaxis for HIV-
- infected individuals with low T-helper cell counts are now beginning
- (see notice in "Announcements" section, below). According to Jay
- Lalezari, M. D., co-director of HIV research at Mt. Zion Hospital in San
- Francisco, "CMV is the last major opportunistic infection for which we
- have no prophylaxis, so one is urgently needed. Our studies of oral
- ganciclovir have shown it to be relatively safe and well tolerated, and
- to have demonstrated activity in reducing titers of CMV infection in
- people."
-
- Note: The second and final part of this article will cover
- foscarnet, combination ganciclovir/foscarnet therapy, IVIG, CMVIg,
- MS-109, HPMPC, BW 256, etoposide, and hypericin.
-
- ***** Announcements
-
- ** Oral Ganciclovir CMV Prophylaxis Study Recruiting
-
- A major national study is testing an oral form of the anti- CMV
- drug ganciclovir to see if it can prevent CMV disease in patients who do
- not have it already. This trial is for persons with AIDS and with T-
- helper counts under 100 -- or persons without AIDS and T-helper counts
- under 50. There are various other entry criteria. This study is
- sponsored by Syntex Inc. of Palo Alto, California.
-
- Trial sites are in Atlanta, Berkeley (CA), Boston, Chicago, Dallas,
- Honolulu, Houston, Los Angeles (2 sites), New York (3 sites),
- Philadelphia, Pittsburgh, San Diego, San Francisco (3 sites), and
- Washington, D. C.
-
- For more information about this trial, or to find the phone number
- of a site in one of the above cities, call the AIDS Clinical Trials
- Information Service, 800/TRIALS-A, or see the new edition of the
- AIDS/HIV Treatment Directory (published by AmFAR, the American
- Foundation for AIDS Research), which is expected to be distributed near
- the end of January. As we go to press, this trial is not yet in the
- TRIALS-A database, but that office can give contact phone numbers for
- the sites from a draft copy of the AmFAR directory.
-
- Note: Do not confuse this prophylaxis trial with a separate trial
- of oral ganciclovirf vs. IV ganciclovir for maintenance therapy for
- persons who have already developed CMV disease. This trial, at 22 sites
- throughout the U. S., is about half enrolled, and is recruiting
- volunteers. For more information about it, call 800/TRIALS-A.
-
- ** New York: Hypericin Trial Recruiting, P24 No Longer Needed
-
- The ongoing trial of the antiviral hypericin at New York University
- has been changed to compare oral vs. intravenous doses of the drug;
- previously it only tested intravenous administration. Volunteers no
- longer need to be p24 positive -- an inclusion criterion which had been
- a problem in New York, since the p24 antigen test is not approved for
- medical practice under New York's rules, and therefore many patients in
- that state do not know whether they are p24 positive or not.
-
- For more information about this trial, call New York University at
- 212/263-6565. Or call the AIDS Clinical Trials Information Service,
- 800/TRIALS-A.
-
- Note: Hypericin remains an important experimental treatment; in
- laboratory tests, it has activity against HIV, CMV, and certain other
- viruses. Results of the current trial have suggested that it may need to
- be administered at least daily, probably in oral form, to maintain
- antiviral blood levels, since intravenous administration causes high
- peak concentrations which may cause dose-limiting side effects, while
- leaving blood levels too low for antiviral activity at other times. The
- current trial, using low doses to determine how well the drug is
- absorbed when given orally, will provide data needed to design a later
- trial to test whether oral dosing can be effective.
-
- ** San Francisco, Salt Lake City: Acyclovir-Resistant Herpes
-
- Treatment Trial
-
- Persons with AIDS and one or more lesions of acyclovir- resistant
- herpes may be eligible for a trial of SP-303T, a drug being developed by
- Shaman Pharmaceuticals, Inc., in San Carlos, California, a company which
- develops drugs from rainforest plants. SP-303T is derived from a plant
- long used for treating herpes in South America; it has been found to be
- active against acyclovir-resistant herpes in laboratory tests. The drug
- is applied topically; the first volunteers were treated in January 1993.
-
- For more information about this study, call Julie Calo at San
- Francisco General Hospital, 415/476-9296 ext. 84607; or call Carol
- Bujwit at the University of Utah School of Medicine, 801/581-4878.
-
- ** Tat Inhibitor Support Group Forming -- Baltimore, Boston,
- Cleveland, San Diego
-
- A support group for persons in the current tat inhibitor trial (now
- taking place in the four cities above) is being formed. Persons in this
- trial can call Giacomo Palazzolo in Boston at 617/524-7780, between 9:00
- a.m. and 5:00 p.m. Eastern time. Please note that this is Giacomo's
- home phone and not a hotline or general information number. He cannot
- handle a great many calls, but wants to provide a communication forum
- for persons who are taking the drug.
-
- The current tat trial is now fully enrolled, and not open to new
- patients.
-
- ** San Francisco: Conference on Speech, Hearing, and Vision
- Loss, February 26
-
- "HIV-Related Speech, Hearing, and Vision Loss: A Conference for
- Health Care Providers, Caregivers, and People with HIV," will be held
- February 26 from 8:30 a.m. to 3:30 p.m. at the University of California,
- Laurel Heights Auditorium, 3333 California Street, San Francisco.
- Persons are asked to register by February 12. Fees (including lunch) are
- $40 physician, $25 other professionals, $15 persons with HIV and all
- others, but no one will be turned away for lack of funds. This
- conference is sponsored by several AIDS, vision, and hearing
- organizations.
-
- For more information, call Kathy Abrahamson at 415/431-1481.
-
- ** San Francisco: "Caring for HIV Naturally" Forum
-
- The Traditional, Holistic, and Alternative Treatment Committee of
- ACT UP/San Francisco is sponsoring a four-part forum on alternative
- treatments, on four Saturdays between January 30 and March 13.
-
- The first session, "Nutrition and Exercise," includes four
- speakers: holistic physician Jon Kaiser, M.D., on diet and food
- supplements; Parris Kidd, Ph.D., author of Living with the AIDS Virus --
- A Strategy for Long-Term Survival, on anti- oxidants and the treatment
- of HIV; David Merriweather, assistant to Jonathan Wright, M.D. (who
- received widespread publicity after an FDA raid on Dr. Wright's clinic
- in Kent, Washington) on issues of digestion and assimilation; and Tom
- Riccobuono, on exercise for people with HIV. This session will take
- place Saturday, January 30, 1 p.m. to 5 p.m., in the Davies Medical
- Center, Castro Street and Duboce Avenue, in the Gazebo room.
-
- Later sessions are: Body-Mind-Spirituality, Feb. 13; Cross-
- Cultural Therapies, February 27; and Long-Term Survivors, March 13.
-
- For more information, or to check locations of later sessions, call
- ACT UP/San Francisco's information hotline at 415/621-0291.
-
- ** AIDS Czar Issue: Report to President or Report to HHS?
-
- ACT UP/New York has begun a letter writing campaign after hearing
- reports that the Donna Shalala, the new Secretary of Health and Human
- Services (HHS) wants the new "AIDS czar" promised by Clinton to report
- to her, instead of directly to the President. ACT UP believes that the
- decision may be made soon. No "AIDS czar" has been appointed yet.
-
- There has been widespread consensus that such a position sould
- report directly to the President -- one reason being that AIDS issues
- involve many departments, not only HHS. "The rationale for the position
- requires the immediate attention and direct access to the President,
- with special powers to coordinate, across all governmental agencies and
- branches, the federal government's response to AIDS. It also requires
- the full commitment of the President to use his office as a from ACT
- UP/New York letter to President-Elect Clinton).
-
- As this issue went to press, United for AIDS Action also joined the
- effort to have an AIDS coordinator in the White House.
-
- For more information on this issue and on how you can help, call
- ACT UP/New York, 212/564-AIDS, or Eric Sawyer, 212/864- 5672.
-
- ***** Resource List, January 1993: ACT UP Affiliates, Buyers'
- Clubs, and PWA Coalitions
-
- Updated by Tadd Tobias
-
- The following is a directory of AIDS activist groups, buyers' c
- coalitions. It includes local and regional contacts for individuals who
- want to get involved with AIDS activism or for those seeking
- experimental treatments or community support services. We have only
- listed phone numbers which we could verify; some of these are home
- telephones, not offices.
-
- For information about new ACT UP affiliates, contact the ACT UP
- Network, 414/483-0376. For information about new PWA coalitions,
- contact the National Association of People Living With AIDS (NAPWA),
- 202/898-0414. If you know of organizations which you think should be
- included in our next directory, please contact this writer at
- 415/255-0836.
-
- The classifications are: "A" -- local activist and direct action
- groups; "B" -- buyers' clubs for alternative or experimental treatments;
- "C" -- coalitions and community networks organized by and for people
- living with AIDS.
-
- ALABAMA
- Birmingham Birmingham AIDS Outreach 205/322-4197C
- AIDS Action Coalition 205/533-2437 C
- ARIZONA
- Phoenix ACT UP/Phoenix 602/433-4966 A
- Phoenix Phoenix Body Positive 602/264-7414 C
- Tucson La Frontera Center/Positively Native 602/770-7418 C
- Tucson PWA Coalition Tucson 602/770-1710 BC
- ARKANSAS
- Little Rock Arkansas AIDS Brigade 501/372-7473 A
- CALIFORNIA
- Fresno ACT UP/Fresno 209/843-2748 A
- Lompoc ACT 805/736-5136 A
- Long Beach Being Alive Long Beach 310/495-3422 C
- Los Angeles ACT UP/Los Angeles 213/669-7301 A
- Los Angeles Being Alive 310/667-3262 C
- Oakland ACT UP/East Bay 510/836-4401 A
- Orange Cty ACT UP/Orange County 714/253-0185 A
- Palm Desert Alternative Supplem. Club 619/568-1725 B
- Redondo Beach Being Alive South Bay 310/544-2702 C
- San Diego ACT UP/San Diego 619/280-2961 A
- San Diego Being Alive San Diego 619/291-1400 C
- San Francisco Healing Alternatives 415/626-2316 B
- San Francisco ACT UP/Golden Gate 415/252-9200 A
- San Francisco ACT UP/San Francisco 415/621-0291 A
- San Mateo San Mateo Cty AIDS Pgm 415/573-2385 C
- Santa Barbara ACT UP/Santa Barbara 805/569-3299 A
- Van Nuys Being Alive 818/908-3840 C
- Ventura ACT UP/Ventura 805/653-5706 A
- West Hollywood Being Alive 310/854-1327 C
- COLORADO
- Denver ACT UP/Mile High 303/643-1895 A
- Denver PWA Coalition Colora 303/837-8214 BC
- CONNECTICUT
- Bethel AIDS Project Greater Danbury 203/778-2437 C d ACT
- UP/Connecticut 203/224-7428 A
- New Haven ACT UP/New Haven 203/732-2229 A
- DISTRICT OF COLUMBIA
- ACT UP/DC 202/328-2437 A
- Carl Vogel Center 202/289-4898 B
- DC Buyers' Club (DCBC) 202/232-5494 B
- Lifelink 202/789-4090 C
- The Positive Woman 202/529-5447 C
- FLORIDA
- Clearwater AIDS Coalition Pinellas 813/449-2437 C
- Dade County PWA Coalit 305/573-6010 C
- Ft. Lauderdale Health Link 800/447-9242 B
- Gainseville ACT UP/Gainseville 904/495-3525 A
- Jacksonville PWA Coalition 904/398-9292 C
- Miami ACT UP/Miami 305/787-1131 A
- Miami Body Positive 305/576-1111 C
- Miami Cure AIDS Now 305/375-0400 C
- Orlando Trans-AIDS Support Serv. 407/352-2352ABC
- Palm Beach PWA Coalition 407/697-8033 C
- Pompano Beach PWA Coalition Broward County 305/565-9119 C
- Sarasota AIDS Manasota 813/954-6011 C
- Tampa ACT UP/Tampa Bay 813/882-5359 A
- Tampa DACCO 813/223-4648 C
- Tampa PWA Coalition TampaBay 813/238-2887 C
- West Palm B. ACT UP/West Palm Beach 407/433-9222 A
- GEORGIA
- Albany Give For Life Association 912/883-1290 C
- Atlanta T UP/Atlanta 404/874-6782 A
- Atlanta NAPWA Atlanta 404/874-7926 C
- Atlanta Atlanta Buyers' Club 404/874-4845 B
- HAWAII
- Honolulu ACT UP/Hawaii 808/524-7438 A
- Honolulu PWA Coalition 808/948-4792 C
- ILLINOIS
- Chicago ACT UP/Chicago 312/509-6802 A
- Chicago Chicago Wect 312/271-2070 C
- Chicago Options for AIDS Treatments 312/509-5127 B
- Chicago Test Positive Aware Network 312/404-8726 C
- INDIANA
- Indianapolis ACT UP/Indianapolis 317/635-2712 A
- WA Coalition 317/636-2134 C
- Indianapolis Indiana Cares 317/630-9075 C
- IOWA
- Davenport Quad Cities AIDS Coalit. 319/324-8638 C
- KANSAS Kansas City ACT UP/Kansas City 816/753-5930 A
- Topek Positive Action Coalition 913/223-7769 C
- LOUISIANA
- Baton Rouge ACT UP/Capitol 504/343-3375 A
- New Orleans PWA Coalition 504/944-3663 C
- New Orleans ACT UP/New Orleans 504/522-5105 A
- Shreveport ACT UP/Shreveport 318/865-5217 A
- MAINE
- Portland ACT UP/Portland Maine 207/828-0566 A
- Portland PWA Coalition 207/773-8500 C
- MARYLAND
- Baltimore ACT UP/Baltimore 410/837-5203 A
- Baltimore AID Baltimore 410/837-2437AB
- Baltimore PWA Coalition 410/625-1677 C
- MASSACHUSETTS
- Boston ACT UP/Boston 617/492-2887 A
- Bostonon Living Center 617/236-1012 C
- Boston Committee of Ten Thousand 617/344-9634 C
- Boston Multi-Cultural AIDS Coalition 617/442-1622 C
- Boston PWA Coalition Boston 617/266-6422BC
- Boston Positive Directions 617/262-3456 C
- Hyannis Cape Cod AIDS Council 508/778-5111 C
- North Hampton ACT UP/Western Mass 413/584-4213 A
- Provincetown ACT UP/Provincetown 508/487-3049 A
- Provincetown Provincetown Positive 508/487-3998 C
- MICHIGAN
- Detroit ACT UP/Detroit 313/872-2427 A
- Detrt Friends Alliance 313/836-2800 C
- Grand Rapids PWAC Western Michigan 616/363-7689 C
- Grand Rapids Grand Rapids AIDS Resource Center 616/459-9177 C
- MINNESOTA
- Minneapolis ACT UP/Minnesota 612/374-9349 A
- Minneapolis The Aliveness Project 612/822-7946 BC
- MISSISSIPPI
- Jackson PWA/HIV Project 601/373-8610 C
- MISSOURI
- Columbia Mid-Missouri AIDS Proj. 314/875-2437 C
- Positive Action 603/659-8442 C
- NEW JERSEY
- Collingswo S. N.J. 609/854-7578 C
- Fort Lee PWA Coalition N.J. 201/ ACT UP/New Jersey 609/771-6680
- A
- NEW MEXICO
- Albuquerque NMAPLA 505/266-0342 C
- Albuquee ACT UP/Albuquerque 505/268-0378 A
- Santa Fe National Rural AIDS Network 505/986-8337 C
- Santa Fe NMAPLA 505/982-5995 C
- NEW YORK
- Albany ACT UP/Youth Chapter of SUNY 518/432-9279 A
- Albany ACT UP/Albany 518/463-8422 A
- Buffalo AIDS Alliance of Western New York 716/852-6778 C
- Buffalo ACT UP/Western New York 716/881-1459 A
- Long Island ACT UP/Long Island 516/336-1258 A
- Long Island PWA Coalition 516/225-5700 C
- New York City ACT UP/New York 212/564-2437 A
- New York City PWA Health Group 212/255-0520 B
- New York City PWA Coalition New York 212/532-0290 C
- New York City NY AIDS Coalition 212/675-7750 C
- Oneonta ACT UP/SUNY Oneonta 607/432-3814 A
- Utica ACT UP/Utica 315/853-6418 A
- NORTH CAROLINA
- Research Triangle ACT UP/Research Triangle 919/990- 1197 A
- OHIO
- Cincinnati GLMA/ACT UP 513/861-6171 A
- Cleveland ACT UP/Cl228-0162 A
- OKLAHOMA
- Oklahoma City ACT UP/Oklahoma City 405/447-4209 A
- Oklahomher Options 405/728-3222 C
- OREGON
- Portland ACT UP/Columbia 503/240-0377 A
- Portlandregon Minority AIDS Coalition 503/293-5870 C
- PENNSYLVANIA
- Philadelphia ACT UP/Philadelphia 215/925-7121 A
- Philadelphia We The People 215/545-6868 C
- Pittsburgh Cry Out!/ACT UP 412/683-9741 A
- PUERTO RICO
- Rio Piedras Coalition of Positive People 809/753-9443C
- Santura ACT UP de Puerto Rico 809/752-5123 A
- RHODE ISLAND
- Providence Lifeline PWA Coalition 401/421-5344 C
- SOUTH DAKOTA
- Sioux Falls ACT UP/South Dakota 605/332-3966 A
- TENNESSEE
- Nashville 10 C
- TEXAS
- Austin ACT UP/Austin 512/477-2437 A
- AIDS Services of Austin 512/451-2273 C
- Dallas ACT UP Dallas AIDS Resource Center 214/521-5124 C
- Dallas AIDS Services of Dallas 214/941-0523 C
- Dallas DBC Alternatives 214/528-4460 B
- Houston ACT UP/Houston 713/433-2924 A
- Houston PWA Coalition 713/522-5428 C
- UTAH
- Salt Lake City PWA Coalition Utah 801/484-2205 C
- VERMONT
- Brattleboro Vermont PWA Coalition 802/257-9277 C
- WASHINGTON
- Seattle ACe 206/726-1678 A
- Seattle People of Color Against AIDS Ne VIRGINIA
- Morgantown Mtn. State AIDS Network 304/292-9000 C
- WISCONSIN
- Madison ACT Up/Madison 608/251-7985 A
- Milwaukee ACT Up/Milwaukee 414/769-8708 A
- Milwaukee PLWA Coalition of Wisconsin 414/273-7592
- WYOMING
- Casper Wyoming AIDS Project 307/237-7833 C
-
- *****
-
- AIDS TREATMENT NEWS Published twice monthly
- Subscription and Editorial Office:
- P. O. Box 4112141
- 800/TREAT-1-2 toll-free U. S. and Canada
- 415/255-0588 regular office number
- 415/255-4659 fax Editor and Publisher:
- John S. James Medical Reporters:
- Jason Heyman
- John S. James
- Nancy Solomon Reader Services and Business:
- David Keith
- Thom Fontaine
- Tadd Tobias
- Rae Trewartha
- Statement of Purpose: AIDS TREATMENT NEWS reports on experimental and
- standard treatments, especially those available now. We interview
- physicians, scientists, other health professionals, and persons with
- AIDS or HIV; we also collect information from meetings and conferences,
- medical journals, and computer databases. Long-term survivors have
- usually tried many different treatments, and found combinations which
- work for them. AIDS Treatment News does not recommend particular
- therapies, but seeks to increase the options available.
- Subscription Information: Call 800/TREAT-1-2
- Businesses, Institutions, Professionals: $230/year.
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- Special discount for persons with financial difficulties:
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- Please send U.S. funds: personal check or bank draft,
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- ISSN # 1052-4207
- Copyright 1993 by John S. James. Permission granted for noncommercial
- reproduction, provided that our address and phone number are included if
- more than short quotations are used.
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