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- Date: Fri, 29 Jan 1993 15:35:21 NZST
- Sender: STATISTICAL CONSULTING <STAT-L@MCGILL1.BITNET>
- From: David Baird <BAIRDD%LCNCRI-2@LAN.LINCOLN.CRI.NZ>
- Subject: Nei's Genetic Similarity Index
- Lines: 43
-
- I have a client who has presence / absence data for DNA fragments
- from 5 individuals for each of 10 different geographic
- populations of a species of insect. The DNA fragments show as
- bands on a gel. There are a variable number of bands per
- population. The data looks like this:
-
- Band
- Population Individual 1 2 3 4 5 6 7 8 9 ...
- 1 1 0 1 1 0 1 0 0 0 0
- 2 1 1 0 1 1 0 0 0 0
- 3 1 1 0 0 1 0 0 0 0
- 4 1 1 1 1 1 0 0 0 0
- 5 0 0 1 0 1 0 0 0 0
-
- 2 1 0 0 1 0 1 1 1 0 1
- 2 0 0 1 1 0 1 1 1 0
- 3 0 0 1 0 0 1 0 0 0
- 4 0 0 1 1 0 1 1 0 1
- 5 0 0 1 1 0 1 1 1 1
- etc.
- Let x = 1 if the band k is present in population j, individual
- ijk i, and 0 otherwise.
-
- She wants to calculate a similarity matrix betweem populations
- which reflects the number of shared bands between individuals.
- She has a paper by Nei and Li, "Mathematical model for studying
- genetic variation in terms of restriction endonucleases." Proc
- National Acad Sciences USA (1979) which defines a general
- similarity coefficient between populations in a theoretical
- manner without giving any computational formulae.
-
- Could someone who has used this approach, or any other define the
- computational formulae in terms of my data, x , above?
- ijk
-
- Thanks for your help.
-
- David Baird Biometrician
-
- Mail address: AgResearch, PO Box 60, Lincoln, New Zealand
- Internet: BairdD@LAN.Lincoln.CRI.NZ
- Phone: +64 3 325 3011
- Fax: +64 3 325 2946
-