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- Path: sparky!uunet!biosci!agate!spool.mu.edu!darwin.sura.net!fconvx.ncifcrf.gov!fcs260c2!toms
- From: toms@fcs260c2.ncifcrf.gov (Tom Schneider)
- Newsgroups: bionet.molbio.embldatabank
- Subject: Re: promotor and database-search?
- Message-ID: <C1JI6M.IEo@ncifcrf.gov>
- Date: 28 Jan 93 01:15:57 GMT
- References: <1993Jan27.182937.12863@gserv1.dl.ac.uk>
- Sender: usenet@ncifcrf.gov (C News)
- Distribution: bionet
- Organization: Frederick Cancer Research and Development Center
- Lines: 31
- Nntp-Posting-Host: fcs260c2.ncifcrf.gov
-
- In article <1993Jan27.182937.12863@gserv1.dl.ac.uk>
- Bianca (HABERMANN@AIMP.UNA.AC.AT) writes:
-
- | Suppose you had promotor sequences of several - functionally related - genes
- | with a conserved sequence motif in common,
-
- Two sequence recognizers can have identical consensus sequences, and yet
- recognize different patterns. Therefore you should not use consensus
- sequences. Instead, make sequence logos of the sequences you have at hand and
- compare them to the sequence logos of other sites. The results will be highly
- sensitive and mathematically much more sensible.
-
- See:
-
- @article{Stephens.Schneider.Splice,
- author = "R. M. Stephens
- and T. D. Schneider",
- title = "Features of spliceosome evolution and function
- inferred from an analysis of the information at human splice sites",
- journal = "J. Mol. Biol.",
- volume = "228",
- pages = "1124-1136",
- year = "1992"}
-
- Regards,
-
- Tom Schneider
- National Cancer Institute
- Laboratory of Mathematical Biology
- Frederick, Maryland 21702-1201
- toms@ncifcrf.gov
-