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In article <1992Dec24.162039.7890@shearson.com>, anon@foo.bar (a f) writes:
> It is stated in the LSD FAQ that "The mushroom psylocybin cubensis
> contains all four of these indole derivatives [ DMT, DET, psylocin, psylocybin], as well as others". As we all know, DMT and DET are not orally active since MAO enzymes in
psilocybin is certainly the major alkaloid, and psilocin a close
second. I had heard of other indoles such as gramine, baeocystin,
etc. turning up, but I have never read a paper claiming DMT or DET
in mushrooms. Not to say that there isn't, but I'd like to
see a reference first.
> the stomach 'destroy' them. However, in the psylocybin section of the
> _Psychedelic Encyclopedia_ it is stated that if mushrooms are chewed thoroughly for
> approximately five minutes prior to ingestion, the psylocibin will hit in approx. 2-3
> minutes after that, since a good deal of it s absorbed thru the mucous lining in the
> mouth.
I have had them hit in the time it took to eat them (a few minutes)
>
> Now, if that is the case,would not the other indole derivatives such as DMT and DET be
> absorbed thru there as well, thus bypassing the MAO's in the stomach?
> Or are there MAO enzymes in the saliva that would render them inactive?
Someone else will tell us if there is MAO in saliva - I suspect there is.
Chewing pure DMT (YUK!) doesn't work, and I suspect the same could be said
for DET. Even if there were no MAO in saliva, it would be damnded
hard to absorb 50 mg of DMT through the mouth in the necessary
few seconds for activity.
Incidently, McKenna claims, I believe, that mushrooms are potentiated
by harmaline. Whether this is the activation of otherwise inactive
tryptamines (which I doubt given their low proportions) or
whether it is because of a psiloc(yb)in-harmaline interaction,
