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- From: turpin@cs.utexas.edu (Russell Turpin)
- Newsgroups: sci.med
- Subject: Re: virus/retrovirus
- Date: 26 Jul 1992 11:45:44 -0500
- Organization: U Texas Dept of Computer Sciences, Austin TX
- Lines: 16
- Message-ID: <14ukroINNd3f@cs.utexas.edu>
- References: <1992Jul24.134442.9382@bradley.bradley.edu>
- NNTP-Posting-Host: cs.utexas.edu
- Summary: DNA is still involved in retrovirus duplication.
-
- -*----
- In article <1682EB1DD.M20614@mwvm.mitre.org> M20614@mwvm.mitre.org (Hugh Pritchard) writes:
- > Retroviruses cut out one step: They contain *RNA*. When the RNA gets
- > into a cell, it just goes directly to the cell machinery and orders more
- > viruses to be built.
-
- A single strand of RNA would be pretty helpless in the cellular
- environment, which is designed to preserve and replicate from DNA,
- and in which RNA is a mediator, any one piece of which is not
- real important. My understanding is that the RNA of a retrovirus
- is transcribed into DNA using reverse transcriptase, and that this
- DNA is then inserted into the cell's DNA, from which replication
- procedes as with normal virii. Hence, retrovirus replication
- involves one *extra* step, rather than one less step.
-
- Russell
-