When I first started using PCLINK software to download data from my CASIO BOSS M10 to my PC, the download function just would not work in OS/2, even though it worked fine in DOS. The software part of PCLINK worked fine under OS/2, but for a long time I was sure I would never download under OS/2. It took a lot of trial and error until I got it to work properly. In an effort to help someone else who might run into the same problem I am enclosing here the pertinent part of my settings which make PCLINK downloading work just fine under OS/2. Please note that I use SIO here to replace IBM's OS/2 default drivers (COM.SYS and VCOM.SYS) but the same generic settings would work without SIO using IBM's OS/2 default com.sys and vcom.sys.
Basically this disables access to 3 of the COMs and only allows access to the one used for the communication (COM 2 in my case). The hardware timer is enabled.